Explore our flagship chemical building blocks, custom peptide APIs, and pharmaceutical intermediates produced under strict global standards.
Comprehensive Industry Analysis, Chemical Specifications, Synthetic Methodologies & Global Commercial Outlook
5-Chloro-2-bromobenzaldehyde (CAS No. 43192-33-2) represents a highly versatile, difunctional electrophilic aromatic intermediate essential to contemporary organic chemistry, pharmaceutical active pharmaceutical ingredient (API) synthesis, and advanced agrochemical development. Characterized by the simultaneous presence of a reactive aldehyde group, a ortho-bromine atom, and a para-chlorine atom relative to the carbonyl moiety, this chemical building block enables orthogonal cross-coupling reactions (such as Suzuki-Miyaura, Heck, and Sonogashira couplings) alongside nucleophilic additions and reductive aminations.
As modern drug discovery increasingly leverages halogenated aromatic scaffolds to enhance lipophilicity, metabolic stability, and target binding affinity, the global demand for ultra-pure 5-Chloro-2-bromobenzaldehyde has escalated. Global chemical manufacturers and procurement departments require stringent control over impurity profiles—specifically isomer contamination and trace metal residues—to ensure seamless integration into downstream multi-step cGMP syntheses.
The global market for substituted benzaldehydes is driven by rapid expansions in target-specific small molecule therapeutics, oncology pipelines, and high-performance agrochemicals. The introduction of the chlorine atom at position 5 imparts unique electronic withdrawal characteristics across the benzene ring, while the bromine atom at position 2 acts as an ideal leaving group for transition-metal catalyzed C-C and C-N bond formations.
Key procurement hubs across North America, Europe, and the Asia-Pacific region are prioritizing supply chain resilience, seeking export partners capable of delivering metric-ton scale volumes with batch-to-batch consistency exceeding 99.0% purity by High-Performance Liquid Chromatography (HPLC). China's modern manufacturing infrastructure—exemplified by Industry 4.0 integrated smart plants—has positioned Chinese exporters as premier partners for fulfilling these stringent global demands.
| Technical Parameter | Standard Specification | Analytical Method | Commercial Importance |
|---|---|---|---|
| Chemical Name | 5-Chloro-2-bromobenzaldehyde | IUPAC Nomenclature | CAS Registry Identification |
| CAS Registry Number | 43192-33-2 | CAS Database | Global Regulatory Compliance |
| Molecular Formula | C7H4BrClO | Mass Spectrometry (MS) | MW: 219.46 g/mol |
| Purity (Assay) | ≥ 99.0% (Custom ≥ 99.5%) | HPLC-UV (254 nm) | Prevents downstream byproduct formation |
| Physical Appearance | Off-white to pale yellow crystalline powder | Visual Inspection | Ease of handling & dissolving |
| Melting Point Range | 64.0 °C – 68.0 °C | Automated Melting Point Apparatus | Crystallinity and solvent dryness indicator |
| Single Impurity | ≤ 0.3% | HPLC Peak Area Normalized | Critical for regulatory DMF filings |
| Water Content (Karl Fischer) | ≤ 0.5% | Karl Fischer Coulometric Titration | Prevents moisture hydrolysis in metal couplings |
| Heavy Metals / Trace Ash | ≤ 20 ppm / ≤ 0.1% | ICP-MS / Gravimetric | Ensures catalyst performance in organometallics |
Optimizing Reaction Kinetics, Continuous Flow Chemistry, and Environmental Sustainability
Traditional bromination of substituted benzaldehydes often suffers from poor regioselectivity, leading to unwanted regioisomers (such as 4-chloro-2-bromobenzaldehyde) that are difficult to purge via recrystallization. Modern Chinese export factories utilize advanced electrophilic bromination protocols using mild Lewis acid catalysts (e.g., FeCl3, AlCl3) under controlled temperature gradients.
By optimizing the electronic activation of the aromatic ring, factory yields are enhanced beyond 92%, while isomer formation is restricted to below 0.15%. This ensures that downstream API manufacturers receive materials that minimize expensive chromatographic purification steps.
Transitioning from traditional batch kettles to continuous flow chemistry represents a core pillar of China's Factory 4.0 transformation. For reactions involving hazardous reagents such as elemental bromine or formylation agents (Vilsmeier-Haack reaction setup), microchannel reactors offer unparalleled heat transfer efficiency and precise residence time control.
This flow chemistry technology eliminates runaway exothermic risks, decreases byproduct formation by over 40%, and provides unmatched batch-to-batch consistency across multiton export orders.
Global pharmaceutical sourcing policies mandate stringent Environmental, Health, and Safety (EHS) compliance. Leading Chinese manufacturing clusters operate under zero-liquid-discharge (ZLD) mandates and integrated waste-gas incineration systems.
By recovering halogenated solvents (such as dichloromethane or dichloroethane) via closed-loop distillation and converting hydrobromic acid byproducts into marketable inorganic salts, export suppliers deliver high-purity intermediates with a significantly reduced carbon and environmental footprint.
Supply Chain Security Note: Reliable manufacturing of 5-Chloro-2-bromobenzaldehyde requires uninterrupted access to basic raw materials including 5-chlorobenzaldehyde, 2-bromotoluene derivatives, and high-purity bromine. Tier-1 Chinese exporters maintain dual-sourcing backward integration to secure raw material supply against market fluctuations.
Enabling Breakthrough Innovations in Pharmaceutical Development, Agrochemicals & Advanced Materials
5-Chloro-2-bromobenzaldehyde is a core synthetic precursor for a wide range of therapeutic agents. Its distinct chemical structure is widely utilized in:
In peptide-drug conjugates (PDCs) and complex hybrid molecules, the aldehyde group allows for efficient reductive amination with modified peptide fragments, while the halogen handles enable cross-linking.
Modern sustainable agriculture requires targeted, low-dose crop protection solutions. 5-Chloro-2-bromobenzaldehyde is heavily specified in:
Because agrochemical synthesis operates under tight margin constraints, China’s ability to deliver high-volume export shipments with cost-effective pricing is a crucial market driver.
Combining Fine Chemical Synthesis, Peptide APIs, and End-to-End Supply Chain Management
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
With an overall factory construction area of 250,000 square meters under international standard, we offer flexible, scalable and cost-effective solutions for clients worldwide. Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are fully supported to customers worldwide.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Stay updated with the latest breakthroughs in peptide active ingredients, intermediate synthesis, and regulatory developments.
Introduction to Selank Acetate API: Selank Acetate API is a synthetic heptapeptide active pharmaceutical ingredient composed of the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. Originally developed through neuropharmacological research...
View Details
Trusted Thymosin Beta-4 API Manufacturer and Global Peptide Supplier: As a professional Thymosin Beta-4 API manufacturer and supplier, we provide high-quality Thymosin Beta-4 peptide API solutions for biotechnology companies and clinical research...
View Details
Introduction: BPC-157 API is a synthetic pentadecapeptide that has gained increasing attention in peptide research due to its potential biological activities related to tissue repair, gastrointestinal protection, and inflammatory regulation...
View Details
With the continuous development of neuroscience, peptide technology, and life science research, neuroactive peptides have become an important area of scientific investigation. Semax, derived from an ACTH fragment, features unique targeted molecular traits...
View Details
SS-31 API, also known as Elamipretide, MTP-131, Bendavia, is a synthetic mitochondria-targeting tetrapeptide designed to bind cardiolipin in the inner mitochondrial membrane, stabilizing mitochondrial bioenergetics...
View DetailsAddressing Common Technical, Analytical, Regulatory, and Logistics Inquiries for Global Buyers
Our standard commercial grade guarantees ≥ 99.0% purity by HPLC area normalization. For highly sensitive API synthesis, we supply specialized batches tested up to ≥ 99.5% purity, with individual specified impurities controlled below 0.10%.
Isomer formation is controlled by utilizing catalytic regioselective bromination protocols in microchannel reactors. Precise temperature management prevents over-bromination and misplacement, ensuring strict compliance with tight impurity limits.
Every shipment includes a comprehensive Certificate of Analysis (CoA), SDS (Safety Data Sheet), HPLC and GC-MS chromatograms, FTIR spectrum, and Loss on Drying (LOD) analytical reports. ASMF/DMF supporting technical packages are available upon request.
5-Chloro-2-bromobenzaldehyde should be stored in tightly sealed, light-resistant containers under inert gas (nitrogen flush) at 2°C to 8°C. Prolonged air exposure should be avoided to prevent oxidation of the aldehyde group to the corresponding benzoic acid.
Standard packaging includes 1 kg / 5 kg aluminum foil vacuum bags for sample/pilot quantities, and 25 kg UN-approved fiber drums with double PE liners for commercial production. Custom packaging is supported for OEM/contract manufacturing orders.
We operate compliant international logistics setups with established global representatives (including hubs in Mexico and South Africa). We provide complete EU REACH compliance, dangerous goods (DG) transport certification, and hassle-free customs clearance support.
Browse our expanded portfolio of raw material ingredients and custom synthesis offerings.
![Buy Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH Manufacturers, Products](https://site.cdnfile.io/www.gentolexchemicals.com/d499c45499c42e867ffd3c50b9686f2c300_300.webp)
