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In-depth analysis of chemical properties, synthesis pathways, industrial scalability, and global trade parameters of Ethyl 4-oxopiperidine-1-carboxylate (CAS 29976-53-2).
1-Ethoxycarbonyl-4-piperidinone (also recognized as Ethyl 4-oxopiperidine-1-carboxylate, CAS No. 29976-53-2) possesses the molecular formula C8H13NO3 and a molecular weight of 171.19 g/mol. It functions as a key piperidine derivative containing both a ketone group at C-4 and a carbamate protective group at N-1. This structural dual-functionality provides versatile reactivity for nucleophilic additions, reductive aminations, and condensation reactions.
Commercial manufacturing leverages the Dieckmann cyclization of diethyl N-(ethoxycarbonyl)-3,3'-dipropionate, followed by controlled decarboxylation. Optimized catalytic conditions utilize sodium ethoxide in absolute ethanol to maximize yield (>94%) while suppressing unwanted side-condensations. Continuous flow micro-reactors are integrated into modern Chinese manufacturing plants to maintain ultra-precise temperature profiles (78°C–82°C) and reduce batch variability.
Gentolex enforces strict Quality Control (QC) standards via High-Performance Liquid Chromatography (HPLC) coupled with Refractive Index and UV-Vis detectors. Gas Chromatography (GC) residual solvent analysis guarantees compliance with ICH Q3C limits (Class 2 and Class 3 solvents < 50 ppm). Water content is strictly controlled below 0.2% via Karl Fischer titration to preserve reagent stability during long-distance oceanic freight.
| Analytical Parameter | Guaranteed Specification | Typical Batch Test Results (Gentolex Standard) | Test Methodology |
|---|---|---|---|
| Chemical Name | Ethyl 4-oxopiperidine-1-carboxylate | 1-Ethoxycarbonyl-4-Piperidinone | IUPAC Nomenclature |
| CAS Registry Number | 29976-53-2 | 29976-53-2 | CAS Verification |
| Appearance | Clear liquid to light yellow viscous liquid | Conforms (Colorless to pale yellow liquid) | Visual Inspection |
| Purity (Assay by HPLC) | ≥ 98.5% | 99.64% | HPLC-UV (210 nm) |
| Refractive Index (n20/D) | 1.4670 – 1.4710 | 1.4688 | Refractometry |
| Density (25°C) | 1.132 – 1.140 g/cm³ | 1.135 g/cm³ | Pycnometry |
| Boiling Point | 110°C - 114°C / 3 mmHg | Conforms | Distillation Metrics |
| Water Content (Karl Fischer) | ≤ 0.5% | 0.08% | Karl Fischer Titration |
| Single Individual Impurity | ≤ 0.5% | 0.12% | Area Normalization (HPLC) |
Analyzing how 1-Ethoxycarbonyl-4-Piperidinone powers critical advancement in pharmaceutical APIs, agrochemicals, and specialty polymer additives across primary economic regions.
1-Ethoxycarbonyl-4-piperidinone serves as an indispensable scaffold for central nervous system (CNS) active pharmaceutical ingredients, analgesics, antihistamines, and neurokinin receptor antagonists. The ethoxycarbonyl group serves as a robust N-protecting group, allowing selective alkylation, reduction, or functionalization at the 4-position ketone without ring degradation. European and North American bio-pharmaceutical labs rely heavily on this building block for rapid high-throughput screening libraries.
In modern agricultural chemistry, piperidine-based ring systems synthesized from Ethyl 4-oxopiperidine-1-carboxylate play a pivotal role in creating novel fungicides, selective herbicides, and targeted insecticides. By forming spiro-heterocyclic ring systems via the ketone core, agrochemical manufacturers produce high-potency crop protectants with lower environmental persistence and enhanced bio-degradability metrics.
The industrial chemical sector utilizes piperidinone derivatives to produce specialized Hindered Amine Light Stabilizers (HALS). These chemicals prevent thermal degradation and UV-induced photo-oxidation in automotive polymers, solar panel encapsulates, and industrial coatings, significantly extending structural life cycles under extreme outdoor exposure.
Connecting the global scientific community with robust chemical manufacturing, contract development (CDMO), and optimized cross-border supply chain networks.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, with dedicated international procurement and distribution representatives established in Mexico and South Africa.
Our main services focus on supplying peptide APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, and end-to-end Sourcing & Supply Chain Solutions. With an overall manufacturing footprint spanning 250,000 square meters constructed under strict international cGMP standards, Gentolex delivers flexible, scalable, and cost-effective commercial solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations.
Custom chemical synthesis, peptide optimization, and route selection for complex heterocyclic molecules and specialized intermediate precursors.
For clients preferring to avoid multiple points of contact, we provide extra customized procurement services with superior supply chain integration.
Understanding the strategic structural advantages of sourcing 1-Ethoxycarbonyl-4-Piperidinone directly from top-tier Chinese manufacturing ecosystems.
| Supply Chain Metric | China Exporter Standard (Gentolex Model) | EU / Western European Suppliers | North American Domestic Suppliers |
|---|---|---|---|
| Raw Material Integration | 100% Upstream Integrated (Basic Petrochemicals to Final Intermediates) | Partial reliance on imported precursors | High reliance on imported primary building blocks |
| Production Capacity & Scale | Multi-ton commercial batch production (250,000 m² footprint) | Pilot to mid-scale commercial runs | Higher unit-cost, smaller batch runs |
| Cost Optimization Index | 30% – 45% lower total cost of procurement | Baseline benchmark cost | 1.5x to 2x higher overhead and labor cost |
| Export Packaging & Cold Chain | ISO-Tanks, 200L UN-rated steel drums, nitrogen-blanketed containers | Standard drum packaging | Standard domestic tote containers |
| Lead Time to Global Ports | Direct freight routes from Ningbo/Shanghai (14-21 days global dispatch) | Localized regional distribution | Regional domestic shipping |
By establishing localized sourcing for key precursor reagents (such as ethyl acrylate and amine building blocks), Chinese plants eliminate supply disruption risks associated with international raw material transport bottlenecks.
Automated inline spectrographic analysis ensures batch-to-batch chemical identity and eliminates physical parameter deviations prior to drumming and international dispatch.
Whether requiring 25 kg pilot validation drums or multi-metric ton commercial supply agreements, Gentolex adapts reaction vessel allocation to meet enterprise scaling demands smoothly.
Mitigating cross-border trade risks through robust regulatory documentation and dedicated local presence in key trade hubs.
Gentolex ensures full compliance with EU REACH registration guidelines, US TSCA inventory standards, and GHS-compliant hazard labeling (Pictograms: GHS07 Irritant). Complete Safety Data Sheets (SDS/MSDS) are available in over 15 languages.
To eliminate time-zone frictions and simplify customs clearance, Gentolex operates regional offices in Mexico and South Africa. These hubs assist Latin American and African procurement officers with localized invoicing, warehouse staging, and technical consultations.
Whether shipping via air freight for urgent R&D validation samples or sea freight ISO-tanks for industrial manufacturing, our logistics division manages hazardous cargo documentation, temperature-monitored transit, and customs declarations end-to-end.
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View Product DetailsClear, direct answers regarding commercial procurement, analytical verification, synthesis routes, and global shipment parameters for 1-Ethoxycarbonyl-4-Piperidinone.
