Explore our specialized commercial products, peptide APIs, and synthetic intermediates manufactured to rigorous cGMP standards.
A comprehensive engineering analysis of 2-Furoyl Chloride (CAS: 527-69-5) synthesis, physicochemical behavior, and industrial acylating capabilities.
2-Furoyl Chloride (also termed Furan-2-carbonyl chloride or 2-Furan-carbonyl chloride, CAS Number: 527-69-5) represents a pivotal heterocyclic acylating agent in fine chemical synthesis and API manufacturing. Featuring a aromatic furan ring coupled directly to a reactive carbonyl chloride function ($\mathrm{C_5H_3ClO_2}$), this organochlorine compound serves as a indispensable building block for introducing the furoyl moiety into complex target molecules.
Due to the electron-withdrawing nature of the carbonyl chlorine combined with the resonance stabilization of the furan ring, Furoyl Chloride exhibits exceptional reactivity toward nucleophilic attack by primary and secondary amines, alcohols, and thiols. This high reactivity makes it the primary reagent for synthesizing furoate esters, furoamides, and heterocyclic intermediates utilized in corticosteroid APIs and agricultural fungicides.
| Parameter | Analytical Specification | Testing Methodology |
|---|---|---|
| Appearance | Clear, colorless to light yellow or reddish liquid | Visual Inspection |
| Assay (GC) | ≥ 99.5% | Gas Chromatography (FID) |
| 2-Furoic Acid Content | ≤ 0.3% | HPLC / Titration |
| Free Chlorine / HCl | ≤ 0.1% | Argentometric Titration |
| Boiling Point | 172.0 °C – 174.0 °C at 760 mmHg | ASTM D1078 |
| Density (20°C) | 1.324 – 1.328 g/cm³ | Pycnometer / Digital Density Meter |
| Refractive Index (n20/D) | 1.498 – 1.502 | Refractometry |
| Residue on Ignition | ≤ 0.05% | Gravimetric Analysis |
How modern OEM chemical manufacturing transitions from traditional batch chlorination to micro-reactor continuous flow chemistry.
Historically, 2-furoyl chloride is synthesized via the action of thionyl chloride ($\mathrm{SOCl_2}$) or phosgene derivatives on 2-furoic acid derived from bio-based furfural oxidation. While straightforward, batch chlorination suffers from heavy off-gas production ($\mathrm{SO_2}$ and $\mathrm{HCl}$) requiring extensive multi-stage scrubbing towers and precise thermal management due to exothermic degradation risks.
At Gentolex, our advanced continuous micro-fluidic flow system operates under precisely controlled pressure and temperature gradients. By mixing 2-furoic acid with highly efficient phosgenation agents or oxalyl chloride inside silicon-carbide micro-channels, reaction dwell time is reduced from hours to seconds, yielding assay purity consistently exceeding 99.5% with reduced impurity formation.
Our target roadmap integrates closed-loop recovery systems where generated acidic gas side-streams are quantitatively converted into high-purity technical hydro-chloric acid and sodium sulfite derivatives. This sustainable circular economy design aligns with strict international Environmental Protection Agency standards and carbon-footprint reduction initiatives.
From global pharmaceutical active ingredients to specialty biopolymers and agrochemical synthesis.
Furoyl chloride serves as the fundamental intermediate in the manufacturing of vital therapeutic compounds. Key medical applications include:
In modern agricultural chemistry, furan-ring derivatives derived from 2-furoyl chloride demonstrate unique systemic fungicidal and insecticidal activity. Furoyl acylations yield broad-spectrum protection compounds against rust fungi, powdery mildew, and crop pathogens with lower soil persistence compared to chlorinated aromatics.
Beyond bio-pharma, furoyl chloride is extensively utilized in polymer synthesis to engineer high-thermal stability bio-based polyesters and polyamides. By replacing petroleum-derived terephthaloyl chloride with furan-based di-carbonyl monomers, material scientists produce sustainable polymers exhibiting superior oxygen and moisture barrier performance for high-end electronics packaging.
Why leading global pharmaceutical conglomerates choose Gentolex Group as their strategic contract chemical manufacturer.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
With an overall factory construction area of 250,000 square meters under international standards, we offer flexible, scalable, and cost-effective chemical and peptide manufacturing solutions. Our integrated supply chain mitigates raw material price volatility, ensuring uninterrupted commercial deliveries worldwide.
View Corporate Profile
End-to-end industrial service offerings tailored for chemical, biological, and pharmaceutical enterprises.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Dedicated contract development and continuous process optimization for novel therapeutic molecules, custom peptide synthesis, and active compounds.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Rigorous safety handling, global REACH registration, and regional hubs in Mexico and South Africa.
2-Furoyl chloride is a moisture-sensitive, highly corrosive liquid. Gentolex supplies product in heavy-duty UN-approved packaging options designed to prevent hydrolysis:
We provide complete regulatory filings to support client drug applications and industrial permits across jurisdictions:
Expert answers regarding storage stability, synthetic compatibility, quality control, and OEM procurement.
2-Furoyl Chloride reacts vigorously with atmospheric moisture to form 2-furoic acid and toxic hydrochloric acid gas. It must be stored in a dry, cool (2°C to 8°C recommended for long-term storage), well-ventilated location under a dry nitrogen pad in hermetically sealed containers.
Our manufacturing facilities utilize high-efficiency fractional distillation under high vacuum, followed by online Gas Chromatography monitoring. Every lot undergoes strict QC testing including FTIR, GC-FID assay, and residual acid titration prior to nitrogen purging and container filling.
Yes. Gentolex specializes in custom peptide synthesis, custom organic intermediate synthesis, and specialized acyl chlorides. We can perform custom esterification, amidation, and ring-modification reactions from milligram scale up to multi-ton commercial production.
With commercial stock maintained in our central facilities and direct support via regional representatives in Mexico and South Africa, standard lead times range from 1 to 3 weeks for international sea/air freight compliant with dangerous goods (DG Class 8) shipping regulations.
Stay updated with research breakdowns, regulatory updates, and peptide active pharmaceutical ingredient innovations.
Explore additional specialized synthetic compounds, hormones, and high-purity peptides available for direct factory export.
