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1. Molecular Architecture & Chemical Specifications of N-(3-Aminopropyl)-Imidazole

Comprehensive analytical profile, chemical constants, and quality thresholds for buyers and process chemists.

N-(3-Aminopropyl)-Imidazole (CAS NO: 5036-48-6), also systematically referred to as 1-(3-aminopropyl)imidazole or 3-(1H-imidazol-1-yl)propan-1-amine, represents a pivotal bifunctional organo-chemical building block. Featuring both a primary aliphatic amine center and a nucleophilic, basic imidazole ring system, this molecule exhibits exceptional reactivity in crosslinking polyurethanes, curing epoxy resins, formulating anti-corrosive coatings, and synthesizing complex active pharmaceutical ingredients (APIs).

Property Parameter	Technical Specification Value	Testing Method / Standards
CAS Registry Number	5036-48-6	International Chemical Identifier
Molecular Formula / Weight	C₆H₁₁N₃ \| 125.17 g/mol	Calculated Stoichiometry
Appearance	Clear, colorless to light yellow liquid	Visual Inspection
Chemical Purity (GC)	≥ 99.0% (Industrial & Pharma Grade)	Gas Chromatography (FID)
Water Content (Karl Fischer)	≤ 0.20% max	ASTM E203 Direct Titration
Boiling Point	288.0 °C to 292.0 °C at 760 mmHg	Standard Atmospheric Distillation
Density & Refractive Index	1.049 g/cm³ at 25°C \| n20/D 1.512	Pycnometer / Refractometer
Flash Point	146.5 °C (Closed Cup)	Pensky-Martens Method

Information Gain Insight: Bifunctional Synergism

Unlike mono-functional amines or rigid imidazoles (such as 1-methylimidazole), CAS 5036-48-6 contains a flexible three-carbon propyl spacer arm between the primary amine ($-\text{NH}_2$) and the aromatic imidazole nitrogen. This structural arrangement minimizes steric hindrance, facilitating rapid nucleophilic attack during epoxy curing while maintaining latent thermal activation channels in polymer matrices.

2. Synthesis Technology Roadmap & Continuous Flow Innovations

Evaluating scalable industrial manufacturing pathways and green engineering transitions.

Traditional Two-Step Batch Reaction

Historically, N-(3-Aminopropyl)-Imidazole is synthesized via the Michael addition of imidazole to acrylonitrile in the presence of a basic catalyst, generating 3-(1H-imidazol-1-yl)propanenitrile intermediate. Subsequent catalytic hydrogenation over Raney Nickel or Cobalt catalysts yields the final primary amine. Traditional batch methods often suffer from localized overheating, byproduct oligomerization, and thermal degradation.

Gentolex Continuous Flow Micro-Reactors

Gentolex has upgraded its core production lines to high-throughput continuous flow micro-channel reactors. By meticulously optimizing mass transfer and micro-scale heat dissipation during cyanoethylation and catalytic hydrogenation, our process minimizes thermal exposure, limits secondary amine side-products to <0.1%, and ensures an ultra-pure final distillate with predictable batch-to-batch consistency.

3. China Factory Supply Chain Resilience & Cost-Efficiency Advantages

Why sourcing N-(3-Aminopropyl)-Imidazole directly from Gentolex ensures competitive stability.

Upstream Raw Material Integration

Located within China's major chemical industrial clusters, Gentolex maintains direct pipeline access to key precursors including imidazole and acrylonitrile. This backwards integration insulates global buyers from raw material price volatility.

250,000 m² Scalable Plant Base

Our state-of-the-art facility features automated multi-ton reactors capable of meeting both commercial metric-ton shipments and custom laboratory batch requirements with rigid adherence to safety and environmental standards.

Global Logistics & Intermodal Efficiency

Strategic proximity to deep-water ports (Ningbo/Shanghai) enables swift export processing, UN-rated dangerous goods packaging compliance, and streamlined customs clearance for international clients across North America, Europe, and Asia.

4. Localized Industrial Application Scenarios & Performance Deep Dive

Unpacking specific technical use cases of CAS 5036-48-6 across high-value global manufacturing sectors.

A. Epoxy Resin Curing Agent & Catalyst Accelerator

In structural adhesives, industrial floor coatings, and electronic encapsulants, N-(3-Aminopropyl)-Imidazole functions both as a primary curing hardener and a potent accelerator for dicyandiamide (DICY) or anhydride curing systems. The imidazole core provides catalytic ring-opening of epoxide groups, imparting high glass transition temperatures ($T_g > 150^\circ\text{C}$), superior chemical resistance, and exceptional tensile adhesion to metallic substrates.

B. Polyurethane (PU) Foams & Elastomer Additives

In PU foam production, maintaining precise balance between blowing (water-isocyanate) and gelling (polyol-isocyanate) reactions is critical. The tertiary nitrogen of the imidazole ring acts as an efficient blowing/gelling catalyst, while the terminal aliphatic amine covalently incorporates into the polyurethane polymer backbone, preventing catalyst emission and minimizing VOC odor in automotive and furniture applications.

C. Pharmaceutical API Synthesis & Peptide Coupling

As a versatile intermediate, CAS 5036-48-6 is widely utilized in therapeutic molecule synthesis, including antifungal compounds, anti-hypertensive drugs, and customized bio-conjugates. In solid-phase peptide synthesis (SPPS) and liquid-phase modification, the primary amine group allows clean derivatization with carboxyl functionalized molecules under standard coupling reagents (EDC/HBTU).

D. Corrosion Inhibition & Metal Surface Treatment

In industrial water cooling systems and metalworking fluids, N-(3-Aminopropyl)-Imidazole forms protective, self-assembled coordination chemisorption layers on copper, brass, and carbon steel surfaces. The electron lone pairs on the imidazole nitrogens bond with metal d-orbitals, drastically reducing oxidative pitting and galvanic corrosion in aggressive aqueous environments.

E. Agrochemical Intermediates & Plant Protection

The chemical structure provides an essential pharmacophore for crop protection chemistry. Synthetic chemists employ 1-(3-aminopropyl)imidazole to construct broad-spectrum azole fungicides and plant growth regulators, ensuring improved systemic uptake and enhanced field bio-activity against common fungal pathogens.

5. Global Commercial Status, Regulatory Compliance & Localized Support

Fulfilling regional regulatory frameworks and offering localized support structures.

Global Market Overview

The demand for N-(3-Aminopropyl)-Imidazole continues to surge across North America, the European Union, and Asia-Pacific driven by expanding structural resin manufacturing, automotive lightweighting polymers, and bio-pharmaceutical research. Global procurement teams prioritize suppliers capable of delivering multi-ton lots backed by rigorous batch documentation and compliance certificates.

Regulatory & Safety Compliance

Gentolex ensures total transparency across all global regulatory landscapes. Every batch of CAS 5036-48-6 is delivered with standard documentation:

REACH Registration Dossier (EU Compliance)
TSCA Inventory Status (USA)
GHS Compliant Safety Data Sheets (SDS in 15+ languages)
CoA (Certificate of Analysis) with GC, NMR & Moisture Analysis

About Gentolex Group & Enterprise Infrastructure

Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.

Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.

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Major Product Lines & Capabilities

Chemicals Products

An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.

Pharmaceutical Ingredients

Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.

Development

Custom synthesis, scale-up validation, and contract manufacturing under strict quality assurance frameworks.

Procurement Service

For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.

Global Certifications & Associated Partners

Verified quality benchmarks supporting chemical supply chain excellence worldwide.

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Frequently Asked Questions (FAQ) & Procurement Intent Guidance

Direct technical answers to common queries submitted by industrial buyers and synthetic organic chemists.

Q1: What purity grade does Gentolex guarantee for N-(3-Aminopropyl)-Imidazole (CAS 5036-48-6)?

Gentolex supplies commercial N-(3-Aminopropyl)-Imidazole at a certified purity of ≥99.0% determined by Gas Chromatography (GC-FID). Moisture levels are strictly controlled to ≤0.20% by Karl Fischer titration. Custom analytical verification including 1H-NMR, 13C-NMR, and Mass Spectrometry (MS) can be attached with each batch order.

Q2: How is CAS 5036-48-6 packaged and transported internationally?

As a corrosive liquid chemical (Class 8 UN-rated dangerous goods), our product is packed in heavy-duty 200L UN-certified steel drums (200kg net), 1000L IBC totes, or custom glass/HDPE containers for smaller research quantities. Nitrogen blanketing is applied prior to sealing to eliminate atmospheric carbon dioxide absorption and oxidation.

Q3: What are the primary advantages of N-(3-Aminopropyl)-Imidazole over traditional amine hardeners in epoxy formulations?

The structural combination of an aliphatic primary amine and a heterocyclic imidazole ring provides a unique dual-curing profile. The primary amine reacts readily at lower temperatures, while the imidazole ring functions as a latent accelerator at elevated temperatures, leading to higher thermal resistance ($T_g$), reduced viscosity, and improved mechanical toughness compared to standard polyamines like DETA or TETA.

Q4: Can Gentolex provide REACH registration documentation for EU imports?

Yes, Gentolex supports European clients with full REACH compliance registration dossiers, standard Safety Data Sheets (SDS) matching Regulation (EC) No 1907/2006, and Certificate of Origin documentation to facilitate smooth European customs entry.

Q5: What is the typical shelf life and storage protocol for N-(3-Aminopropyl)-Imidazole?

When stored in original unopened containers under cool (15°C - 25°C), dry, and well-ventilated conditions away from direct light and strong oxidizing agents, N-(3-Aminopropyl)-Imidazole has a shelf life of 24 months. Nitrogen purging upon opening is highly recommended to preserve clear color purity.

Q6: How can global customers request a sample batch or bulk quotation?

Procurement teams can submit inquiries directly through our sales desk or localized regional representatives in Mexico and South Africa. Sample batches (100g to 1kg) for laboratory testing are dispatched via specialized chemical express carriers within 48 hours of confirmation.

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