Semaglutide enhances insulin secretion in a glucose-dependent manner, meaning it increases insulin release only when blood sugar levels are elevated. This helps improve blood sugar levels and reduces the risk of hypoglycemia.

Glucagon is a hormone produced by the pancreas that plays a key role in regulating blood sugar levels by stimulating the liver to release glucose into the blood. By inhibiting the release of glucagon, semaglutide helps lower blood sugar levels in people with diabetes. By reducing glucagon levels, semaglutide further helps maintain healthy blood sugar levels, which is particularly beneficial for people with type 2 diabetes.