Explore our top-tier chemical building blocks, pharmaceutical intermediates, and specialized APIs manufactured in full compliance with international cGMP standards and ISO quality protocols.
Unsymmetrical Dimethylethylenediamine (commonly designated as N,N-Dimethylethylenediamine, DMEDA, or 2-dimethylaminoethylamine; CAS Registry Number: 108-00-9) is an essential aliphatic diamine characterized by the co-existence of both a primary amine (-NH₂) and a tertiary amine (-N(CH₃)₂) functional group within a single compact ethylene backbone. This dual-functionality imparts unique structural reactivity, basicity, and coordination chemistry, establishing DMEDA as an indispensable chemical intermediate in modern pharmaceutical synthesis, agrochemical manufacturing, industrial gas treatment, and advanced polymer formulations.
As global regulatory frameworks demand higher purity profiles for Active Pharmaceutical Ingredients (APIs) and specialty chemicals, chemical buyers and procurement directors are increasingly seeking verified exporters capable of providing enterprise-grade supply stability, minimal moisture content (<0.2%), and documented analytical transparency (CoA, GC-MS, FTIR, and HPLC).
| Parameter | Technical Specification / Standard Value | Testing Methodology |
|---|---|---|
| Chemical Name | N,N-Dimethylethylenediamine / Unsym-Dimethylethylenediamine | IUPAC Standard |
| CAS Registry Number | 108-00-9 | CAS Index |
| Molecular Formula / Weight | C₄H₁₂N₂ / 88.15 g/mol | Mass Spectrometry |
| Assay Purity (GC) | ≥ 99.5% (Pharma & Synthetic Grade) | Gas Chromatography (FID) |
| Moisture Content (Water) | ≤ 0.20% (w/w) | Karl Fischer Titration |
| Boiling Point | 104.0 °C to 107.0 °C @ 760 mmHg | ASTM D1078 |
| Density (20°C) | 0.807 g/cm³ | Pycnometer / Digital Density Meter |
| Appearance | Clear, colorless to light yellow liquid | Visual Inspection |
The global demand for Unsymmetrical Dimethylethylenediamine is experiencing sustained compound annual growth driven by expanding applications across medical chemistry, polymer cross-linking, agricultural formulation chemistry, and carbon capture solutions.
DMEDA serves as a crucial pharmacophore building block in the synthesis of first- and second-generation antihistamines (such as Pyrilamine, Antazoline, and Mepyramine), anti-arrhythmic agents, local anesthetics, and custom peptide intermediate couplings.
Utilized as a high-activity curing agent for epoxy resins and as a blowing/gelation catalyst in flexible and rigid polyurethane foam systems. Its tertiary amine center accelerates cross-linking polymerization kinetics.
Acts as a precursor for polyamino carboxylic acids and specialized chelating ligands capable of sequestering transition metals in industrial water conditioning, textile processing, and electroplating baths.
Incorporated into the synthesis of selective herbicides, fungicides, and plant growth regulators. DMEDA derivatives enhance lipophilicity and bioavailability across plant cell membranes.
Quaternization of DMEDA produces cationic surfactants, anti-static agents, and corrosion inhibitors used extensively in oilfield chemicals and advanced lubricant formulations.
Emerging applications leverage DMEDA's high amine density for reversible carbon dioxide adsorption in post-combustion capture systems and natural gas sweetening processes.
When sourcing Unsymmetrical Dimethylethylenediamine globally, international buyers face challenges related to purity consistency, pricing volatility, and long lead times. Chinese manufacturers, led by enterprise groups like Gentolex, have engineered distinct operational and technological edges that streamline bulk procurement:
China's robust petrochemical infrastructure provides direct, uninterrupted access to essential precursors such as Dimethylamine (DMA), Ethylene Oxide (EO), and Aziridine derivatives. Upstream integration reduces input cost fluctuation and guarantees long-term contract stability.
Modern chemical plants in China have transitioned from traditional batch reactors to continuous micro-channel reactor systems. This results in precise thermal management, minimal side-reactions, reduced dimer formation, and ultra-high batch-to-batch reproducibility.
With modern manufacturing facilities spanning over 250,000 square meters built under international standards, chemical suppliers can seamlessly scale output from pilot-scale multi-kilogram batches to multi-ton metric container shipments.
For research scientists, synthetic organic chemists, and plant process engineers, understanding the reactivity matrix of Unsym-Dimethylethylenediamine is vital for optimizing yield and reducing chromatographic purification steps.
Under stoichiometric control at 0–5°C in the presence of mild organic bases (e.g., Triethylamine or Pyridine), DMEDA reacts exclusively via its primary amino group with acyl chlorides or anhydrides to yield N-(2-(dimethylamino)ethyl)amides. The tertiary amine remains unreacted, serving as an internal basic handle for aqueous acid-base extraction.
Reaction of DMEDA with aldehydes or ketones in the presence of sodium triacetoxyborohydride [NaB(OAc)₃H] or sodium cyanoborohydride [NaBH₃CN] provides secondary and tertiary unsymmetrical diamine derivatives with yields routinely exceeding 92%.
DMEDA acts as a bidentate [N,N] chelating ligand in organometallic catalysis. It stabilizes palladium(II), copper(I/II), and nickel(II) centers in C-N cross-coupling reactions (Buchwald-Hartwig amination) and aerobic oxidation cycles.
The chemical manufacturing industry is undergoing a structural transition toward carbon footprint reduction, zero-wastewater discharge, and strict REACH registration compliance. Leading suppliers of Unsym-Dimethylethylenediamine are adapting through five strategic trends:
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Browse through our expanded portfolio of fine chemical intermediates, plasticizers, peptides, and functional compounds available for global bulk supply.
