OEM Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH Company, Products

This compound is a protected, functionalized lysine derivative used in peptide synthesis and drug conjugate development. It features an Fmoc group for N-terminal protection, and a side-chain modification with Eic(OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), and AEEA (aminoethoxyethoxyacetate). These components are designed to study lipidation effects, spacer chemistry, and controlled drug release. It is widely researched in the context of prodrug strategies, ADC linkers, and membrane-interacting peptides.

 

Product Description

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Research Application

This compound is a protected, functionalized lysine derivative used in peptide synthesis and drug conjugate development. It features an Fmoc group for N-terminal protection, and a side-chain modification with Eic(OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), and AEEA (aminoethoxyethoxyacetate). These components are designed to study lipidation effects, spacer chemistry, and controlled drug release. It is widely researched in the context of prodrug strategies, ADC linkers, and membrane-interacting peptides.

Function

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH serves as a building block for synthesizing lipid-modified peptides or drug delivery systems. The Eic moiety improves lipophilicity and membrane binding; γ-Glu adds enzymatic stability and targeting potential; and AEEA acts as a flexible hydrophilic linker. Together, they enable the construction of peptides with enhanced cellular uptake, extended half-life, and site-specific delivery properties.

Frequently Asked Questions (FAQ)
Q: What is Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH?
It is a protected, functionalized lysine derivative used as a specialized building block in peptide synthesis and drug conjugate development.
Q: What key structural components are present in this compound?
It features an Fmoc group for N-terminal protection, alongside a side-chain modification consisting of Eic(OtBu) (an eicosanoic acid derivative), γ-glutamic acid (γ-Glu), and AEEA (aminoethoxyethoxyacetate).
Q: What is the role of the Eic moiety in peptide modifications?
The Eic moiety improves lipophilicity and enhances membrane binding capabilities of the synthesized peptides.
Q: How do γ-Glu and AEEA contribute to peptide functionality?
γ-Glu adds enzymatic stability and targeting potential, while AEEA serves as a flexible hydrophilic linker.
Q: What are the main research applications for this compound?
It is widely researched for studying lipidation effects, spacer chemistry, controlled drug release, prodrug strategies, ADC linkers, and membrane-interacting peptides.
Q: How does this derivative enhance drug delivery systems?
Combined together, its integrated components enable the construction of peptides with superior cellular uptake, an extended half-life, and site-specific delivery properties.

Related Products