4-Methoxyphenylacetone, systematically designated as 1-(4-methoxyphenyl)propan-2-one and widely recognized in industrial chemistry as p-Anisylacetone or 4-Methoxybenzyl methyl ketone (CAS Registry Number: 122-84-9), serves as a pivotal chemical building block. This organo-chemical compound possesses the molecular formula C10H12O2 and a molecular weight of 164.20 g/mol.
As an aromatic ketone carrying a methoxy group at the para-position relative to the propan-2-one side chain, 4-methoxyphenylacetone exhibits exceptional chemical reactivity. It is heavily relied upon by multi-national pharmaceutical developers, specialty flavor and fragrance houses, fine chemical synthesis plants, and agricultural technology innovators worldwide.
High-purity grade (≥99.5% by GC/HPLC) 4-Methoxyphenylacetone is essential for eliminating side reactions during multi-step pharmaceutical Active Pharmaceutical Ingredient (API) synthesis, drastically increasing total reaction yields and lowering processing overhead.
Commercial chemical procurement requires rigorous analytical validation. Premium Chinese manufacturers enforce stringent quality control protocols utilizing Gas Chromatography (GC-FID), High-Performance Liquid Chromatography (HPLC), Proton NMR (1H-NMR), and Karl Fischer titration to guarantee specifications across batch deliveries.
| Analytical Parameter | Technical Specification Standard | Testing Methodology | Industrial Significance |
|---|---|---|---|
| Appearance | Clear pale yellow to colorless liquid | Visual Inspection | Indicates absence of oxidative degradation or polymeric impurities. |
| Chemical Purity (Assay) | ≥ 99.5% (Pharma Grade) / ≥ 98.5% (Tech Grade) | Gas Chromatography (GC-FID) | Maximizes chemical yields during subsequent synthetic steps. |
| Boiling Point | 267.0 °C to 269.0 °C at 760 mmHg | Differential Scanning Calorimetry (DSC) | Confirms structural purity and absence of lower-boiling solvents. |
| Density / Specific Gravity | 1.069 g/mL at 25 °C | Digital Pycnometer | Ensures proper volumetric dosing in automated batch reactors. |
| Moisture Content (Water) | ≤ 0.10% w/w | Karl Fischer Coulometric Titration | Prevents hydrolytic degradation of water-sensitive catalysts. |
| Refractive Index ($n_D^{20}$) | 1.525 - 1.529 | Refractometry | Rapid optical verification of substance identity. |
| Single Impurity Profile | ≤ 0.20% maximum individual impurity | HPLC / GC-MS | Crucial for pharmaceutical API regulatory compliance. |
| Heavy Metals Content | ≤ 10 ppm total (Lead, Cadmium, Arsenic) | ICP-MS Validation | Prevents toxic metal contamination in downstream products. |
Utilizing anisole (methoxybenzene) as the primary aromatic precursor, acylation with chloropropanone or chloroacetone in the presence of optimized Lewis acid catalysts (e.g., AlCl3 or modern zeolites) yields 4-methoxyphenylacetone with high regioselectivity toward the para-position.
Aldol condensation of p-anisaldehyde with nitroethane followed by catalytic reduction of the nitroalkene intermediate under controlled hydrogenation conditions offers an exceptionally clean route, yielding target molecules with minimal halogenated by-products.
Leading Chinese manufacturing plants have transitioned from legacy batch kettles to automated continuous flow micro-reactor systems. This technology enables ultra-precise temperature control, prevents thermal runaways, and boosts reaction yield to over 96%.
China has established itself as the undisputed global epicenter for fine chemical manufacturing and pharmaceutical intermediate supply chains. Modern Chinese chemical producers offer key structural advantages that guarantee supply security and cost efficiency for international buyers:
Direct access to localized petrochemical hubs providing bulk phenol, methanol, and propionic acid derivatives ensures uninterrupted production runs free from overseas supply disruptions.
Industrial complexes spanning over 250,000 square meters house high-volume synthesis reactors, allowing top suppliers to deliver multi-ton annual capacities at competitive price points.
State-of-the-art Chinese chemical parks operate integrated Zero Liquid Discharge (ZLD) effluent treatment systems and strict safety controls compliant with international ISO 14001 guidelines.
Chinese exporters maintain strategic logistical partnerships across global trade routes. With specialized hazardous chemical handling capabilities and rapid maritime clearance through Ningbo, Shanghai, and Qingdao ports, bulk orders are delivered seamlessly worldwide.
Dedicated distribution hubs established in Mexico, South Africa, Germany, United States, Brazil, and India ensure rapid customs dispatch and local warehouse support.
Serves as a fundamental precursor for cardiovascular drugs, therapeutic central nervous system agents, and custom peptide API side-chain linkages.
Utilized by fine fragrance perfumers to impart sweet, anisic, floral, and hawthorn-like top notes in high-end personal care products.
Acts as an essential core intermediate in the development of systemic fungicides, selective herbicides, and crop-protection bio-agents.
Enables advanced organic synthesis, serving as an alkylating reagent and building block in academic chemical research laboratories.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our main services focus on supplying Peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions. Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations.
Technical support, product line setup, custom synthesis validation, and pilot plant scale-up assistance for global pharmaceutical brands.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with superior supply sources.
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Read DetailsWhen selecting a 4-Methoxyphenylacetone manufacturer, procurement officers must mandate complete batch-specific documentation: Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), Gas Chromatogram (GC), Mass Spectrometry (MS), and ISO 9001 quality management standard certificates.
Industrial chemical shipments require UN-certified packaging protocols. Premium suppliers offer fluorinated HDPE drums (25kg, 200kg), steel-plastic composite drums, and temperature-monitored ISO tank containers equipped with nitrogen blanketing to prevent moisture absorption and oxidation during transit.
Verify that your Chinese supplier possesses active EU REACH registrations, US TSCA inventory compliance, and expertise in navigating customs declarations for organic chemical intermediates to avoid customs delays at target destination ports.
Evaluate factory reactor volumes and continuous process flow capabilities to ensure seamless scale-up from R&D kilo-lab quantities to commercial multi-ton batch deliveries with flexible payment terms (LC, TT) and transparent incoterms (FOB, CIF, DDP).
