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Deciphering the Technical Architecture, Synthetic Vectors, and Commercial Procurement Landscape of Ethyl 4-Oxo-1-Piperidinecarboxylate
Ethyl 4-Oxo-1-Piperidinecarboxylate (CAS: 4128-73-8 / 90923-06-7) represents a vital heterocyclic building block. Featuring a piperidone core functionalized with an N-1 ethyl carbamate protecting group, it exhibits exceptional reactivity for nucleophilic additions and condensation chemistry required in advanced drug synthesis.
Driven by expanding pipelines in Central Nervous System (CNS) therapeutics, metabolic disease APIs, and specialty peptidomimetics, multinational procurement teams require scalable, highly validated OEM manufacturing partners capable of multi-ton annual outputs with ultra-pure specs.
High-grade commercial sourcing requires stringent impurity profiling (HPLC > 99.5%, single unknown < 0.10%), ICH Q3C residual solvent compliance, complete spectra verification (NMR, MS, FT-IR), and regulatory audit-ready DMF/REACH documentation packages.
Unlike standard intermediate sourcing, securing Ethyl 4-Oxo-1-Piperidinecarboxylate requires evaluation of the manufacturer's catalytic hydrogenation controls and carbamylation efficiency. Preventing trace aromatic amine residues and ensuring structural stability under varying humidity parameters are critical indicators of supplier technical maturity.
In-depth analysis of key physical properties, reaction kinetics, and impurity mitigation strategies.
| Parameter / Parameter Name | Technical Specification / Standard | Analytical Methodology |
|---|---|---|
| Chemical Name | Ethyl 4-oxo-1-piperidinecarboxylate / 1-Carbethoxypiperidin-4-one | IUPAC Standard / Structure Verification |
| CAS Registry Number | 4128-73-8 (Base Derivative: 90923-06-7) | CAS Index Verification |
| Molecular Formula & Weight | C8H13NO3 | 171.19 g/mol | High-Resolution Mass Spectrometry (HRMS) |
| Appearance | Clear pale yellow to colorless liquid / Low melting solid | Visual Inspection Standard |
| Chemical Purity (HPLC) | ≥ 99.5% Area Percentage | High-Performance Liquid Chromatography |
| Single Individual Impurity | ≤ 0.10% | HPLC Peak Area Normalized |
| Water Content (Karl Fischer) | ≤ 0.50% w/w | Karl Fischer Coulometric Titration |
| Heavy Metals Content | ≤ 10 ppm total | ICP-MS (Inductively Coupled Plasma) |
| Residual Solvents | Complying with ICH Q3C Limits (Methanol < 3000ppm, Toluene < 890ppm) | Headspace Gas Chromatography (GC-HS) |
The enterprise-scale synthesis of Ethyl 4-Oxo-1-Piperidinecarboxylate generally utilizes one of two industrial pathways:
Gentolex's chemical engineering teams utilize micro-channel continuous flow reactors for the carbamylation stage. This eliminates hot-spot formation, minimizes side-product polymerization, and maintains an exceptionally tight purity spectrum exceeding 99.5% consistently across 50-ton batch outputs.
Empowering Global Life Sciences and Chemical Enterprises with Turnkey Supply Chain Infrastructure.
An overall factory construction area of 250,000 square meters under international standards to offer flexible, scalable, and cost-effective chemical manufacturing solutions globally.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standards from long-term collaborations. Full documentation (DMF, CoA, ROS, MSDS) is fully supported.
Providing specialized tech transfer, synthetic pathway optimization, hazard assessment, and pilot scale-up services tailored for challenging heterocyclic and peptide-mimetic chemistry.
For clients preferring to avoid the complexity of dealing with multiple vendor touchpoints, we provide customized procurement services leveraging superior, integrated global supply chain sources.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our core focus spans across supplying active pharmaceutical ingredients (APIs), custom peptides synthesis, FDF license-out operations, comprehensive technical support & consultation, industrial product line & lab setups, and streamlined supply chain logistics solutions.
Meeting Rigorous International Pharmacopeial and Environmental Standards for Seamless Cross-Border Sourcing.
Every commercial batch of Ethyl 4-Oxo-1-Piperidinecarboxylate manufactured within our network complies strictly with ICH Q7 guidelines for active pharmaceutical ingredient intermediates. Analytical validation procedures adhere to ICH Q2(R1) validation protocols.
For European Union and North American importers, navigating registration, evaluation, authorization, and restriction of chemicals (REACH) is crucial. Gentolex guarantees full tonnage coverage, standard safety data sheet (SDS) compliance under GHS Rev 8, and pre-cleared tariff documentation.
Implementing green chemistry principles, our production plants incorporate atom-economic catalytic reduction techniques, solvent recovery systems with dynamic vapor recovery, and zero-liquid-discharge (ZLD) effluent treatment facilities.
Next-Generation Continuous Flow Synthesis and AI-Driven Process Optimization for Piperidine Derivatives.
Transitioning from batch synthesis to fully automated continuous flow micro-reactor networks. This technology eliminates batch-to-batch variance, improves heat transfer efficiency, and stabilizes volatile organic reagents during the carbamylation step.
Integrating machine learning analytics with real-time in-line Process Analytical Technology (PAT)—such as ReactIR and online HPLC—to predict, identify, and eliminate trace byproduct formation before crystallisation.
Forming regional distribution hubs and raw material buffer stocks across key target nodes in Latin America (Mexico) and Africa (South Africa) to insulate partners from maritime freight volatility and raw material bottlenecks.
Collaborating with accredited pharmaceutical enterprises, analytical centers, and chemical distributors worldwide.
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View DetailsTechnical, Regulatory, and Procurement Queries regarding Ethyl 4-Oxo-1-Piperidinecarboxylate
Our baseline OEM commercial grade maintains an HPLC purity of ≥ 99.5% with no single unknown impurity exceeding 0.10%. Customized specifications up to 99.9% purity are available upon request for sensitive clinical-stage applications.
Ethyl 4-Oxo-1-Piperidinecarboxylate should be stored under nitrogen blanketed, air-tight containers protected from moisture and elevated temperatures (typically 2°C to 8°C or cool room storage at 15°C–25°C). Standard export packaging includes UN-approved fluorinated HDPE drums, stainless steel drums, or custom insulated totes with temperature monitoring tags.
Yes. Gentolex provides full regulatory support, including Open Part DMF documentation, Certificate of Analysis (CoA), High-Resolution Mass Spectrometry (HRMS), 1H-NMR / 13C-NMR data, FT-IR spectra, and residual solvent analysis complying with ICH Q3C guidelines.
For research and pilot testing, MOQs start from 1 kg. For enterprise OEM commercial contracts, standard batch sizes range from 100 kg to multi-metric-ton lots. Lead times vary between 2 to 4 weeks for stocked catalog batches and 6 to 8 weeks for custom synthetic campaigns.
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