High-purity chemical compounds manufactured to rigorous international quality parameters for global bio-pharmaceutical applications.
Benzaldehyde, 2-bromo-5-chloro- represents a critical halogenated aromatic building block used extensively in global organic synthesis, pharmaceutical manufacturing, and modern agrochemical R&D. Characterized by its dual halogen substitution (bromine at position 2 and chlorine at position 5) relative to the formyl functional group, this versatile intermediate enables complex coupling chemistry, including Suzuki-Miyaura cross-couplings, Buchwald-Hartwig aminations, and regioselective electrophilic aromatic additions.
As pharmaceutical supply chains prioritize high-purity, structurally predictable synthons to minimize downstream impurity profiles, securing a reliable, cGMP-compliant wholesale supplier for 2-Bromo-5-Chlorobenzaldehyde is paramount for commercial success.
| Chemical Name: | 2-Bromo-5-Chlorobenzaldehyde |
| CAS Registry No: | 156682-52-9 (Primary Synthon) |
| Molecular Formula: | C7H4BrClO |
| Molecular Weight: | 219.46 g/mol |
| Assay / Purity: | ≥ 99.0% (HPLC Normalized) |
| Physical Appearance: | Off-White to Pale Yellow Solid/Crystalline |
| Water Content (K.F.): | ≤ 0.5% max |
Understanding the reaction kinetics, catalytic mechanisms, and structural versatility of 2-bromo-5-chlorobenzaldehyde in advanced organic synthesis.
The manufacturing process for high-purity 2-bromo-5-chlorobenzaldehyde involves carefully controlled electrophilic bromination and chlorination of substituted benzaldehyde precursors. Achieving high yield demands catalytic precision to prevent over-halogenation and regioisomeric contamination at positions 3, 4, or 6.
The presence of orthogonal halogen substituents (bromine and chlorine) provides synthetic chemists with differential reactivity. The bromine atom at position 2 undergoes facile palladium-catalyzed organometallic cross-coupling reactions (e.g., Suzuki, Sonogashira), while the 5-chloro position offers a secondary site for targeted functionalization.
The highly reactive aldehyde moiety serves as an ideal anchor for Schiff base formation, reductive amination, and Wittig olefination reactions. This enables rapid assembly of complex bicyclic heterocycles and pharmacophores active in oncology, neurology, and cardiovascular research.
Bridging global chemical supply demands with rigorous quality assurance, continuous production capabilities, and strategic raw material security.
Global pharmaceutical entities faced significant vulnerabilities during recent supply chain disruptions due to single-source chemical dependency. Halogenated intermediates like 2-bromo-5-chlorobenzaldehyde demand multi-ton production capacity backed by reliable raw material pipelines for bromine and chlorine reagents.
Procurement teams require partners capable of providing scalable quantities—from pilot-scale kilograms to multi-ton commercial volumes—without compromising on batch-to-batch purity standards or encountering export control bottlenecks.
By leveraging large-scale modern manufacturing facilities spanning over 250,000 square meters, industrial suppliers can insulate global buyers from price volatility and product shortages. Advanced automated reaction monitoring, real-time HPLC purity tracking, and inventory buffer management ensure uninterrupted manufacturing schedules for contract research organizations (CROs) and commercial API manufacturers globally.
Uncompromising commitment to analytical rigour, regulatory compliance, and total quality management across the product lifecycle.
Strict spectral validation of starting materials via FT-IR, GC-MS, and elemental analysis prior to reactor loading.
Real-time quantitative tracking using UHPLC to monitor reaction conversion rates and eliminate side-product formation.
Optimized solvent crystallization systems ensuring final product purity exceeds 99.0% with minimal heavy metal residue.
Complete Certificate of Analysis (CoA), SDS, REACH registration data, and UN-certified hazard packaging for air/sea export.
Creating opportunities connecting the world with reliable services, guaranteed products, and international standard chemical engineering.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations.
Advanced custom synthesis development, scalable route optimization, and technical support consultation for novel chemical entities.
Customized procurement services with superior supply chain sources for clients preferring to avoid complex multi-vendor management.
Driving continuous innovation in halogenated chemical synthesis through sustainable continuous-flow reactors and eco-friendly catalytic processes.
Transitioning traditional batch halogenation processes to continuous-flow microreactors. This technology minimizes heat transfer resistance, reduces hazardous bromine exposure, and increases product yields by up to 14%.
Implementing closed-loop solvent recovery units across all production lines. By recovering up to 98% of volatile organic solvents, we dramatically reduce carbon footprint and industrial waste output.
Integrating AI-driven mass spectrometry and NMR analysis to predict reaction kinetics in real-time, preventing isomer contamination before crystallisation stages take place.
Navigating global chemical commerce requires localized expertise, precise regulatory filings, and robust compliance management. Gentolex maintains dedicated overseas representative hubs, including active operations in Mexico and South Africa, enabling rapid regional response, localized billing, and seamless customs clearing.
Our regulatory team supports client compliance with international chemical frameworks, including:
Stay informed with technical research, API updates, and peptide synthesis engineering from the Gentolex expert scientific team.
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View Details →Expert technical answers regarding storage, reaction parameters, bulk order procedures, and product documentation.
Our standard commercial grade guarantees ≥ 99.0% purity as validated by High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC). Custom purification up to 99.5% is available upon request for specific pharmaceutical coupling applications.
Products are packed under nitrogen atmosphere in fiber drums with double polyethylene inner liners (typically 25 kg/drum) or UN-approved HDPE containers to prevent ambient moisture absorption and oxidation of the aldehyde functional group.
Store in a cool, dry, well-ventilated area away from direct light and strong oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Always wear appropriate PPE (chemical-resistant gloves, protective goggles) during handling.
Yes. Supported by our 250,000 square meter infrastructure and specialized organic synthesis laboratories, we provide contract custom synthesis, functional group transformations, and scale-up services for modified benzaldehyde analogs.
Every commercial shipment includes a comprehensive Certificate of Analysis (CoA), 1H-NMR spectrum, HPLC chromatogram, Material Safety Data Sheet (MSDS/SDS), and relevant REACH/TSCA compliance verification documents.
Standard catalog quantities ship within 3–5 business days. Commercial multi-ton orders typically carry a production and dispatch timeline of 2–4 weeks, supported by full logistics tracking through our regional hubs in Mexico, South Africa, and Asia.
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