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4-Methoxyphenylacetic acid (also designated as p-Anisylacetic acid or 4-Methoxybenzeneacetic acid) is a vital aromatic organocompound functioning as a key building block in modern medicinal chemistry and organic synthesis. Exhibiting a crystalline solid state under ambient conditions, its precise electron-rich benzene ring coupled with a carboxylic acid moiety makes it exceptionally reactive for targeted acyl substitution, condensation, and catalytic coupling reactions.
When sourcing 4-Methoxyphenylacetic Acid from modern factory setups, evaluating structural identity via 1H-NMR, mass spectrometry (MS), and quantitative High-Performance Liquid Chromatography (HPLC) is essential. Modern pharmaceutical production demands strict limits on related substances (individual unknown impurities < 0.10%, total impurities < 0.50%), residual solvent thresholds matching ICH Q3C guidelines, and low heavy metal counts.
| Parameter Specification | Technical Standard Value | Analytical Testing Methodology |
|---|---|---|
| Chemical Name | 4-Methoxyphenylacetic Acid / p-Anisylacetic Acid | IUPAC Nomenclature Standard |
| CAS Registry Number | 104-01-8 | Chemical Abstracts Service Identification |
| Molecular Formula / Weight | C9H10O3 / 166.17 g/mol | Mass Spectrometry (ESI-MS) |
| Purity Grade (HPLC) | ≥ 99.5% Commercial Standard | High-Performance Liquid Chromatography |
| Melting Point Range | 85.0 °C – 88.0 °C | Capillary Melting Point Apparatus |
| Loss on Drying (LOD) | ≤ 0.5% max | Thermogravimetric / Vacuum Oven Drying |
4-Methoxyphenylacetic Acid acts as a high-value core intermediate across multiple high-tech chemical sectors, supporting lifesaving active pharmaceutical ingredient (API) synthesis and specialized polymer formulations.
In modern drug discovery and pharmaceutical production, 4-Methoxyphenylacetic acid is an indispensable precursor for cardiac therapies, beta-blocker APIs, anti-inflammatory compounds, and anti-platelet agents. Its methoxy-substituted aromatic ring provides optimal steric and electronic profiles required for bio-active receptor target binding.
Beyond human pharmaceuticals, the compound serves as an essential building block in crop protection chemistry. Synthetic routes for modern herbicides, selective fungicides, and plant growth regulators utilize 4-MPAA to enhance bio-availability and targeted metabolic resistance within agricultural formulations.
Due to its mild, sweet aromatic profile and versatile esterification capability, derivatives of 4-Methoxyphenylacetic acid are widely used in sensory chemical engineering. Esters derived from 4-MPAA are integrated into complex fragrance formulations, food-grade aromatics, and fine chemical additives.
When evaluating 4-Methoxyphenylacetic acid manufacturers, technical procurement managers must ensure the factory provides batch-to-batch consistency in particle size distribution (PSD) and trace impurity control. Micro-impurities such as unreacted anisole or structural isomers (3-methoxyphenylacetic acid) can cause significant yield drop in downstream multi-step API synthesis.
Understanding the modern industrial synthesis routes to ensure sustainable cost efficiency, high yield purity, and minimal environmental footprint.
Industrial scale production frequently utilizes anisole as a raw precursor, undergoing catalytic chloromethylation followed by cyanation and subsequent acid hydrolysis to yield high-purity 4-Methoxyphenylacetic acid. Modern green-chemistry facilities have upgraded this pathway using direct catalytic carbonylation under high-pressure gas reactors to eliminate hazardous cyanide byproducts.
An alternative industrial pathway involves 4-methoxyacetophenone via the Willgerodt-Kindler reaction with sulfur and morpholine, followed by alkaline hydrolysis. Advanced factory setups employ continuous-flow microreactors that shorten reaction residency times, dramatically boost thermal control, and optimize total energy consumption during mass production.
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Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
From initial R&D pilot plant synthesis to metric-ton scale manufacturing, our technical engineering team guarantees seamless scalability and analytical transparency.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
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Buy Tirzepatide Powder for Injection for Weight Loss 30mg Per Vial Purity 99% Product, Products
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Our industrial production standard guarantees an HPLC assay purity of ≥ 99.5%. Each commercial batch is thoroughly analyzed via High-Performance Liquid Chromatography, 1H-NMR, and Karl Fischer titration to ensure strict adherence to international pharmaceutical intermediate requirements.
Every order is dispatched with a comprehensive Certificate of Analysis (COA), Safety Data Sheet (SDS / MSDS compliant with GHS regulations), HPLC chromatogram trace, and stability report. DMF documentation and REACH registration packages are available upon request for regulatory filing support.
We accommodate both research-scale evaluation orders (1 kg – 25 kg fiber drums with double PE liner bags) and large multi-ton bulk commercial shipments (palletized 500 kg UN-approved big bags or customized steel drums).
Gentolex operates direct regional representative hubs in Mexico and South Africa, facilitating localized customs clearing, rapid technical response, and efficient air/sea freight distribution across North America, Latin America, Europe, and Africa.
