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Comprehensive chemical specifications, molecular mechanics, and structural characteristics of Sodium Thioglycolate (CAS 367-51-1).
Mercaptoacetic Acid Sodium Salt, widely known in commercial chemical procurement as Sodium Thioglycolate (CAS Number: 367-51-1; Molecular Formula: HSCH2COONa; MW: 114.10 g/mol), is an organosulfur compound characterized by dual functional reactive centers: a nucleophilic free thiol (-SH) group and a carboxylate salt moiety (-COONa).
This unique bifunctional architectural layout imparts high water solubility, intense reducing agent capabilities, and strong heavy metal chelating characteristics. When evaluated by commercial buyers, purchasing managers, and chemical process engineers sourcing directly from certified factories and chemical manufacturing companies, the exact purity profile (typically ≥98.0% or ≥99.0% assay via iodometric titration) governs its suitability across mineral processing, biopharmaceutical disulfide cleavage, personal care formulations, and oilfield chemistry.
| Parameter | Technical Specification | Analytical Method |
|---|---|---|
| Chemical Name | Sodium Mercaptoacetate / Sodium Thioglycolate | IUPAC Standard |
| CAS Registry No. | 367-51-1 | CAS Index |
| Assay (Purity) | ≥ 98.5% (Solid Powder) / 45-50% Liquid Solution | Titration / HPLC |
| Appearance | White to Off-White Powder / Clear Liquid | Visual inspection |
| pH Range | 6.5 – 8.0 (5% aqueous solution) | Potentiometric |
| Iron (Fe) Content | ≤ 10 ppm (High-Purity Grade) | ICP-AES / AAS |
| Heavy Metals (as Pb) | ≤ 5 ppm | USP <231> |
Analyzing global procurement trends, supply chain logistics, and sector-specific consumption for Mercaptoacetic Acid Sodium Salt.
In global froth flotation processing—specifically for copper-molybdenum (Cu-Mo) separation—Mercaptoacetic Acid Sodium Salt acts as an environmentally responsible, highly selective depressant for copper sulfides and pyrite ($FeS_2$), enabling effective flotation recovery of molybdenite ($MoS_2$). Mining enterprises worldwide are increasingly replacing highly hazardous sodium cyanide ($NaCN$) and toxic sodium hydrosulfide ($NaHS$) reagents with sodium thioglycolate formulations due to strict ESG regulations and workplace safety directives.
Within peptide manufacturing and API synthesis, exact redox control is imperative. Sodium mercaptoacetate serves as a precise reducing agent for cleavage of intermolecular disulfide bonds ($S-S$), biochemical assay stabilization, and specialized chemical modification of cysteine residues. Integrated suppliers like Gentolex leverage this chemistry to produce derivative protected amino acids and specialized building blocks engineered for therapeutic peptides.
In oil & gas upstream extraction, hydrogen sulfide ($H_2S$) corrosion poses severe structural risks to downhole drill pipes and transport infrastructure. Sodium Mercaptoacetate acts as a potent scavenger and iron-complexing additive in acidizing fluid treatments, reducing iron ions ($Fe^{3+}$ to $Fe^{2+}$) and preventing ferric hydroxide precipitation, thereby extending machinery lifecycle.
Future-proof chemical synthesis routes, zero-discharge wastewater management, and odor encapsulation technology in sodium thioglycolate production.
Historically, the industrial synthesis of mercaptoacetic acid sodium salt involved reacting chloroacetic acid with sodium hydrosulfide ($NaHS$) or sodium thiosulfate ($Na_2S_2O_3$), producing high concentrations of inorganic salt side-streams. Advanced factories are transitioning to continuous micro-channel reactor technologies with heterogeneous phase-transfer catalysts. This technical evolution enhances stoichiometric yields beyond 96.5%, drastically reduces free sulfide contaminants, and yields ultra-pure crystalline solids preferred by high-end cosmetic and pharmaceutical buyers.
Global buyer persona research indicates that international purchasers demand stringent REACH, RoHS, and cGMP compliance documentation. Manufacturers investing in automated closed-loop distillation, zero-liquid-discharge (ZLD) effluent treatment units, and advanced sulfur odor scrubbing systems enjoy distinct commercial advantages. Gentolex's standard 250,000 square meter standardized plant operational model represents this modern manufacturing paradigm.
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Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective chemical synthesis solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Full technical consultation, turnkey analytical setup, laboratory line design, and process optimization for custom peptide and fine chemical synthesis.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
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Latest technological updates, API manufacturing developments, and scientific publications from Gentolex chemical experts.
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View DetailsAddressing key technical questions regarding Mercaptoacetic Acid Sodium Salt (CAS 367-51-1) procurement, chemical stability, and industrial application protocols.
Chemical factories typically supply two primary commercial grades: Technical Grade (Solid Powder ≥98% or aqueous liquid solution 45-50%) utilized heavily in mining mineral flotation and oilfield H2S scavenging, and Pharmaceutical/Cosmetic Grade (≥99.0% purity with heavy metal content <5 ppm) engineered for peptide chemical synthesis, cosmetics, and cold-wave formulations.
Sodium Mercaptoacetate dissociates in aqueous slurry to form mercaptoacetate anions. These anions selectively chemisorb onto the surface of chalcopyrite ($CuFeS_2$) and pyrite ($FeS_2$) minerals, rendering their surfaces hydrophilic while allowing hydrophobic molybdenite ($MoS_2$) particles to attach to air bubbles and float, achieving superior separation efficiency without cyanide toxicity.
Mercaptoacetic Acid Sodium Salt is hygroscopic and sensitive to atmospheric oxygen, which causes gradual oxidation into sodium dithiodiglycolate. Containers must be tightly sealed under nitrogen blanketing, kept in a dry, cool, well-ventilated area away from strong oxidizing agents and heavy metal catalysts, at temperatures ideally below 25°C.
Yes. Gentolex offers comprehensive OEM procurement and supply chain solutions. Industrial powders are available in 25 kg sealed fiber drums with double PE inner liners or 1000 kg UN-certified IBC totes for liquid formulations. Full analytical documentation including HPLC/Titration CoA, MSDS/SDS, and REACH registration dossiers are included.
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