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Comprehensive Molecular Profile, Synthetic Utility, and High-Purity Industrial Scaling
N-Carbethoxy-4-Piperidone (CAS 29976-53-2), also known as Ethyl 4-oxopiperidine-1-carboxylate, is a pivotal heterocyclic intermediate used extensively in pharmaceutical API synthesis, neuro-active drug development, and specialized fine chemical engineering. This dossier outlines process intensification parameters, cGMP scalability standards, impurity controls, and international logistical protocols essential for global procurement directors.
| Chemical Attribute | Technical Specification & Standard Parameters |
|---|---|
| IUPAC Name | Ethyl 4-oxopiperidine-1-carboxylate |
| CAS Registry Number | 29976-53-2 |
| Molecular Formula / Weight | C8H13NO3 / 171.19 g/mol |
| Assay (Purity via HPLC / GC) | ≥ 99.0% (Commercial Grade) / ≥ 99.5% (High-Purity API Grade) |
| Physical Appearance | Clear pale yellow to light yellow liquid or low-melting crystalline solid |
| Boiling Point / Density | 110-114 °C at 1 mmHg / 1.135 g/cm³ at 25 °C |
| Water Content (Karl Fischer) | ≤ 0.5% max |
| Single Individual Impurity | ≤ 0.2% max |
| Regulatory Standards | Complies with cGMP, ISO 9001:2015, REACH certified packaging standards |
The carbamate-protected piperidone ring system offers dual reactivity centers: a ketone moiety reactive to nucleophilic additions and reducts, alongside a stable ethoxycarbonyl protecting group resilient under mild acidic conditions.
Engineered for international commerce, backed by robust MSDS/SDS dossiers, non-hazardous or classified hazard sea/air transport compliance, and validated cold-chain logistics across America, EU, and Asia.
Manufactured in multi-ton validated facilities with rigorous analytical control via HPLC, GC-MS, and NMR, ensuring zero batch-to-batch variation for downstream clinical API formulation.
Strategic Sourcing Demands for N-Carbethoxy-4-Piperidone Across Major Industry Verticals
The strategic procurement of N-Carbethoxy-4-Piperidone (CAS 29976-53-2) has experienced significant tailwinds due to rapid expansions in pharmaceutical synthesis and custom fine chemistry pipelines. As pharmaceutical entities move towards commercial production of central nervous system (CNS) candidates, analgesics, and specialized receptor modulators, securing reliable, high-volume chemical supply lines becomes paramount.
Global demand spans across critical industrial hubs:
Next-Generation Engineering Pathways for Higher Yields and Eco-Friendly Processing
Transitioning from traditional batch reactor systems to continuous micro-reactor technology allows precise microsecond thermal management, reducing side-reactions, improving yield by up to 14%, and minimizing environmental impact.
Utilizing high-resolution LC-MS/MS coupled with NMR tracking to identify trace degradation products. Our standard guarantees nitrosamine-free and low-residual-solvent intermediates compliant with ICH Q3C guidelines.
Employing reusable heterogenous catalysts and eco-compatible solvent recovery protocols to drive closed-loop synthesis, drastically reducing chemical oxygen demand (COD) in wastewater streams.
Every commercial batch of N-Carbethoxy-4-Piperidone undergoes rigorous quality testing including Certificate of Analysis (CoA) validation, Gas Chromatography-Mass Spectrometry (GC-MS), High-Performance Liquid Chromatography (HPLC) assay checks, and Heavy Metal Residue Analysis prior to export packaging.
Connecting Global Markets with Guaranteed High-Performance Chemical Solutions
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
State-of-the-art synthetic labs and pilot plants dedicated to custom peptide synthesis, route verification, and scale-up optimization.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Seamless International Distribution with Rigorous Quality Verification
Full support for Drug Master Files (DMF), Certificates of Analysis (CoA), SDS (Safety Data Sheets under GHS standards), BSE/TSE declaration, and REACH registration protocols for European imports.
With direct representative centers established in Mexico and South Africa, Gentolex offers on-the-ground regulatory assistance, rapid local customs clearance, and localized regional stocking.
Supplied in 25kg, 50kg, or 200kg UN-certified fluorinated drums, featuring nitrogen flushing and temperature-controlled shipping to preserve chemical stability during cross-border transit.
Clear Answers for Quality Assurance Managers, Procurement Officers, and Chemists
Gentolex supplies standard commercial grades at ≥99.0% assay by GC/HPLC. For active pharmaceutical ingredient (API) synthesis requiring stringent specifications, we provide ultra-high purity batches reaching ≥99.5% with single unknown impurities controlled below 0.10%.
N-Carbethoxy-4-Piperidone should be stored in tightly sealed, light-resistant, air-tight containers under inert gas (nitrogen blanket) at temperatures between 2°C and 8°C. Protect from strong oxidizing agents and moisture to maintain maximum shelf life.
Yes. With a total facility footprint of 250,000 square meters, our synthesis plants operate commercial-scale reactors capable of delivering multi-ton lots per month, equipped with complete batch documentation and validation protocols.
Every shipment is accompanied by a batch-specific Certificate of Analysis (CoA), HPLC/GC chromatograms, NMR identification spectra, Karl Fischer titration results for moisture content, and SDS documentation.
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