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An in-depth evaluation of molecular parameters, synthesis pathways, impurity profiles, and analytical testing protocols from China's leading chemical manufacturers.
CAS 67-48-1, universally recognized in chemical and industrial manufacturing as Choline Chloride (2-hydroxyethyl-trimethylammonium chloride), represents a vital quaternary ammonium salt with the molecular formula C5H14ClNO and a molecular weight of 139.62 g/mol. It exists structurally as a quaternary ammonium cation bonded with a chloride anion, exhibiting strong hygroscopic properties, exceptional water solubility, and high thermal stability under standard industrial processing environments.
As a key organic chemical intermediate and nutritional additive, Choline Chloride functions as a primary methyl donor in biological methylation cycles, a precursor for acetylcholine synthesis, and a critical structural constituent of cell membrane phospholipids (phosphatidylcholine and sphingomyelin). Procurement managers evaluating the China 67-48-1 price landscape must analyze chemical purity, water content, residual solvents, heavy metal thresholds, and carrier choices to ensure technical compatibility with specific downstream applications.
| Technical Parameter | Feed Grade Powder (50% / 60% / 70%) | Liquid Grade Solution (70% / 75%) | Pharma / Synthesis Grade (>99%) |
|---|---|---|---|
| Chemical Name | Choline Chloride on Corn Cob / Silica Base | Aqueous Choline Chloride Solution | Pure Choline Chloride Crystals / Powder |
| CAS Number | 67-48-1 | 67-48-1 | 67-48-1 |
| Assay (Dry Basis) | 50.0% – 70.0% min | 70.0% – 75.0% min | 99.0% – 100.5% min |
| Appearance | Light brown free-flowing powder/granules | Clear, colorless to light amber liquid | White crystalline powder |
| Loss on Drying (Moisture) | ≤ 4.0% | 25.0% – 30.0% (water content) | ≤ 0.5% |
| Heavy Metals (as Pb) | ≤ 10 ppm | ≤ 10 ppm | ≤ 5 ppm |
| Free Trimethylamine (TMA) | ≤ 300 ppm | ≤ 200 ppm | ≤ 10 ppm / Ultra-pure |
| Dioxins & PCBs | EU Compliance Verified | EU Compliance Verified | Pharmaceutical Standard Compliant |
Understanding the pricing mechanisms of CAS 67-48-1 requires deep insight into the primary industrial synthesis routes utilized by chemical factories in China. The predominant commercial process involves the continuous reaction of Ethylene Oxide (EO), Trimethylamine (TMA), and Hydrochloric Acid (HCl):
(CH3)3N + C2H4O + HCl → [HO-CH2-CH2-N(CH3)3]+ Cl-
Because Ethylene Oxide is derived directly from petroleum cracking via ethylene, the FOB China price of Choline Chloride demonstrates strong econometric correlation with global crude oil benchmarks, regional ethylene spot rates, and localized TMA supply dynamics. Top-tier Chinese manufacturers optimize continuous gas-phase and liquid-phase reaction loops to maximize yield efficiency (>98.5%), minimize residual trimethylamine odor, and eliminate toxic reaction byproducts.
How Choline Chloride drives value across animal nutrition, energy exploration, pharmaceutical synthesis, and sustainable green solvent technologies.
Choline Chloride is widely recognized as "Vitamin B4", serving as an indispensable additive in poultry, swine, aquaculture, and ruminant feed formulations. It prevents fatty liver syndrome, perosis in broilers, and enhances muscle mass development. China manufacturers supply over 70% of global feed-grade demand in dry corn-cob carrier (50%, 60%, 70%) and liquid forms.
In unconventional oil and gas extraction, liquid Choline Chloride acts as a highly effective, environmentally friendly clay stabilizer and hydration inhibitor. It prevents swelling and migration of clay minerals in shale formations during hydraulic fracturing operations, outperforming potassium chloride (KCl) while reducing chemical handling costs.
High-purity crystalline Choline Chloride (>99%) is utilized as a active precursor for synthesizing lipotropic therapeutics, neurological acetylcholine boosters, memory-enhancement compounds, and biochemical reagents. Pharmaceutical clients require strict cGMP compliance, zero-microbial limits, and heavy-metal purity verification.
As the scientific community transitions toward green solvent chemistry, Choline Chloride combined with hydrogen bond donors (such as urea, glycerol, or ethylene glycol) forms low-cost Deep Eutectic Solvents (DES). These solvents are revolutionizing metal electroplating, biomass extraction, CO2 capture, and sustainable organic synthesis.
Key economic indicators, commercial contracting strategies, and risk mitigation models for international bulk buyers.
When procuring CAS 67-48-1 from manufacturers in mainland China (primarily concentrated in Shandong, Jiangsu, and Hebei provinces), bulk buyers must navigate several macro pricing factors:
Bridging global chemical markets with uncompromised quality, cGMP standard manufacturing, and seamless procurement logistics.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions. Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
250,000 m² modern factory construction area under international standard delivering scalable solutions.
cGMP standard APIs and intermediates with full regulatory certificates (COA, MSDS, DMF support).
End-to-end custom peptide synthesis, technical support, lab setup consultation, and FDF licensing out.
Integrated supply chain management eliminating multiple vendor touchpoints for global buyers.
Pioneering sustainable chemical production, ultra-pure electronics-grade synthesis, and decarbonized supply chains.
Gentolex and leading manufacturing partners are transitioning toward bio-based ethylene feedstock and zero-carbon catalytic reaction loops, reducing the carbon intensity of CAS 67-48-1 production by up to 35% over the next decade.
Expanding synthesis precision to meet semiconductor cleaning standards (<10 ppb metallic impurities), expanding Choline Hydroxide and Choline Chloride applications in advanced microelectronics manufacturing.
Developing specialized bypass encapsulation technologies for ruminant animal feed, protecting active Choline Chloride against rumen degradation and increasing bio-availability by over 40%.
Direct answers to essential commercial, technical, and regulatory questions for global buyers.
The FOB China price of Choline Chloride (CAS 67-48-1) is predominantly governed by Ethylene Oxide (EO) spot pricing, Trimethylamine (TMA) supply availability, domestic corn cob carrier prices (for dry grades), energy costs, and seasonal feed demand fluctuations. Requesting real-time market quotes from Gentolex ensures access to accurate pricing structures.
Standard export MOQs typically begin at 1 full container load (FCL), which equals approximately 18–20 Metric Tons for dry powder (25kg bags or jumbo bags) or 22–24 Metric Tons for liquid solution in Flexitanks. Customized sample quantities for laboratory testing can be dispatched upon request.
Choline Chloride dry grades are highly hygroscopic. Gentolex utilizes high-barrier double-layer polyethylene (PE) inner liners inside multi-wall woven polypropylene (PP) bags, alongside anti-caking silica additives when requested. Packaging integrity is rigorously tested to withstand high humidity and temperature variations encountered during transit.
All shipments are accompanied by a comprehensive Batch Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), and compliance certifications including FAMI-QS (for animal feed), ISO9001:2015, REACH registration (for European Union buyers), and Halal/Kosher accreditations upon request.
Yes. Gentolex specializes in customized procurement and contract manufacturing. Whether you require specific concentration adjustments, alternative carrier materials (e.g., silica-based for high liquid loading), or specialized peptide/API synthesis, our technical team provides full lab setup and technical support.
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