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An authoritative technical guide on Ipamorelin acetate structure, growth hormone secretagogue receptor (GHS-R1a) selectivity, and industrial peptide production standards.
Ipamorelin (CAS No. 170851-70-4) represents a milestone achievement in the field of synthetic peptide chemistry. As a pentapeptide mimic of ghrelin, its primary sequence—Aib-His-D-2Nal-D-Phe-Lys-NH2—was engineered to exhibit exceptional specificity for the Growth Hormone Secretagogue Receptor 1a (GHS-R1a). Unlike earlier generation growth hormone releasing peptides such as GHRP-2 or GHRP-6, Ipamorelin displays high binding affinity to pituitary receptors without triggering off-target release of cortisol, ACTH, or prolactin.
For global biopharmaceutical developers and enterprise procurement leaders, obtaining consistent, high-purity batch runs of Ipamorelin 5mg lyophilized vials requires stringent chemical control over racemization, trifluoroacetic acid (TFA) counter-ion exchange, and moisture content control.
Gentolex's automated Solid-Phase Peptide Synthesis (SPPS) protocols maintain a strict batch-to-batch purity tolerance (>99.0% by RP-HPLC) with single impurity thresholds under 0.2%, ensuring compliant raw material integration for pharmaceutical research and commercial development.
| Parameter | Technical Specification |
|---|---|
| Chemical Name | Ipamorelin Acetate |
| Molecular Formula | C38H49N9O5 |
| Molecular Weight | 711.85 g/mol |
| CAS Registry Number | 170851-70-4 |
| Purity (RP-HPLC) | ≥ 99.0% (Custom ≥ 99.5% available) |
| Physical State | Lyophilized White Powder |
| Bacterial Endotoxins | < 0.05 EU/mg (Strict research grade) |
| Counter Ion | Acetate (TFA content < 1.0%) |
From resin coupling to controlled lyophilization, our multi-stage quality assurance framework guarantees unparalleled peptide integrity.
Utilizing high-capacity Rink Amide resin, protected Fmoc amino acids (Fmoc-Aib-OH, Fmoc-His(Trt)-OH, Fmoc-D-2Nal-OH, Fmoc-D-Phe-OH, Fmoc-Lys(Boc)-OH) undergo precise automated step-by-step coupling. DIC/Oxyma Pure activation systems minimize racemization at critical histidine residues.
Post-cleavage crude peptides are processed via industrial-scale preparative Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) utilizing C18 columns. Dynamic gradient elution with acetonitrile/water/ammonium acetate efficiently separates target sequences from deletion peptides.
Purified Ipamorelin acetate fractions undergo controlled freeze-drying cycles (primary and secondary drying phases) to achieve moisture levels under 3.0%. Vials are stoppered under sterile nitrogen overlay inside ISO 5 cleanrooms to ensure long-term shelf stability at 5mg dosage.
Leveraging state-of-the-art infrastructure, massive production volume, and seamless logistical integration to serve global enterprise clients.
Gentolex operates an overall factory construction area of 250,000 square meters constructed under rigorous international cGMP standards. By combining automated peptide synthesizers, continuous-flow reactors, and real-time Process Analytical Technology (PAT), we offer flexible, scalable, and cost-effective solutions for clients globally.
Our integrated raw material procurement networks ensure that key building blocks—such as unnatural amino acids and coupling reagents—are sourced with complete traceability, eliminating bottleneck risks during global supply disruptions.
Flexible procurement pathways tailored for biotechnology organizations, pharmaceutical researchers, and commercial brand holders.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions for active pharmaceutical ingredients (APIs) and advanced chemical building blocks.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Full documentation, regulatory dossiers, and certificates are supported for clients worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources worldwide.
Bridging continents through dedicated regional hubs, seamless regulatory documentation, and international logistic standards.
Up to date, Gentolex Group has been serving customers from more than 10 countries. Specifically, regional representatives are established in Mexico and South Africa to deliver localized sales support, rapid clearing coordination, and real-time customer service across American and African markets.
Our main services focus on supplying peptide APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, as well as full-scale Sourcing & Supply Chain Solutions.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products.
Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
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View DetailsAnswers to common technical, analytical, and procurement queries regarding Ipamorelin 5mg supply and custom peptide manufacturing.
Discover our comprehensive portfolio of growth hormone secretagogues, regulatory peptides, and biochemical synthesis reagents.
