Explore our featured enterprise-grade compounds produced under strict ISO/cGMP quality control protocols.
In modern synthetic chemistry and pharmaceutical manufacturing, heterocyclic intermediates serve as the backbone for next-generation drug discovery and commercial API scale-up. Among these critical building blocks, N-Ethoxycarbonyl-4-Piperidinone (CAS Registry Number: 29976-53-2; also identified as Ethyl 4-oxopiperidine-1-carboxylate) holds a premier position. This chemical compound serves as an irreplaceable precursor in synthesizing complex active pharmaceutical ingredients (APIs), neuro-pharmacological agents, analgesics, and specialized peptidomimetic constructs.
N-Ethoxycarbonyl-4-Piperidinone combines a reactive piperidone core with a protective ethoxycarbonyl group. This unique functionality protects the nitrogen atom during electrophilic or nucleophilic additions at the carbonyl site. Our factory achieves high chemical stability and consistent physical characteristics across multi-ton production batches.
As premier exporters, we ensure all batches strictly comply with REACH regulations, TSCA standards, and international safety frameworks. Complete documentation packages including Certificate of Analysis (CoA), Gas Chromatography-Mass Spectrometry (GC-MS), and Nuclear Magnetic Resonance (NMR) spectra are provided for regulatory verification.
Utilizing micro-channel reactor design and automated continuous flow synthesis, our facility reduces processing cycles while enhancing safety and yield consistency. This tech capability isolates volatile byproducts, guaranteeing impurity levels remain strictly below enterprise specifications.
| Parameter Parameter | Standard Specification | Testing Methodology |
|---|---|---|
| Chemical Name | N-Ethoxycarbonyl-4-piperidinone / Ethyl 4-oxopiperidine-1-carboxylate | IUPAC Designation |
| CAS Registry Number | 29976-53-2 | CAS Database Index |
| Molecular Formula | C8H13NO3 | Elemental Analysis |
| Molecular Weight | 171.19 g/mol | High-Resolution MS |
| Appearance | Clear light-yellow to pale brown liquid / low melting solid | Visual Inspection |
| Assay Purity (HPLC/GC) | ≥ 99.0% (Custom high-grade ≥ 99.5%) | GC-FID / LC-MS |
| Water Content (Karl Fischer) | ≤ 0.5% | ASTM E203 (KF Titration) |
| Single Impurity | ≤ 0.2% | Chromatographic Area Normalization |
| Boiling Point | 132 - 134 °C at 7 mmHg (lit.) | Standard Distillation Assay |
| Storage Conditions | 2–8°C, inert gas atmosphere (Nitrogen shielded), tight seal | Stability Testing Protocols |
The demand for piperidine-derived structural motifs has grown dramatically across North America, Western Europe, and the Asia-Pacific region. As pharmaceutical research increasingly pivots toward targeted neuro-therapeutics, highly selective pain management drugs, and complex chemical probes, key raw materials like N-Ethoxycarbonyl-4-Piperidinone experience sustained procurement expansion.
In the United States and Canada, top-tier CROs and CDMOs utilize N-Ethoxycarbonyl-4-Piperidinone as a crucial intermediate for multi-step drug discovery programs. High demand for custom peptide-mimetic research and CNS pipeline development necessitates reliable import channels with robust regulatory compliance packages.
European purchasers demand compliance with strict REACH registrations and environmental impact audits. High-purity exports from verified facilities guarantee low residual solvent profiles (compliant with ICH Q3C guidelines), ensuring seamless integration into downstream API production lines.
As the primary hub for global fine chemical synthesis, the Asia-Pacific region leverages integrated supply chains to provide cost advantages without sacrificing quality. China's scaled manufacturing infrastructure ensures immediate availability for bulk industrial quantities.
Operating from an international-standard production complex spanning over 250,000 square meters, modern Chinese chemical manufacturers have revolutionized intermediate manufacturing through technological innovation, scale integration, and rigorous quality assurance.
By establishing direct supply corridors for fundamental precursors such as piperid-4-one derivatives and ethyl chloroformate, Chinese facilities insulate clients from market price volatility while ensuring an uninterrupted manufacturing process.
State-of-the-art reaction vessels equipped with real-time NIR analytical technology allow for tight process control during the ethoxycarbonylation and purification stages, producing consistent purity assays exceeding 99.5%.
Every shipment undergoes comprehensive quality verification, including HPLC, GC, NMR, and elemental analyses. Quality management protocols adhere to international ISO 9001 and ISO 14001 standards.
Understanding the chemical reactivity of N-Ethoxycarbonyl-4-Piperidinone enables optimization of downstream synthetic steps across various research and commercial domains.
The keto group at the C4 position readily undergoes nucleophilic addition, reductive amination, or Wittig olefination. This makes it an ideal precursor for producing piperidine-containing drug candidates targeting central nervous system pathways, pain mitigation, and oncology therapies.
In modern peptide engineering and peptidomimetic science, incorporating rigid piperidine scaffold structures allows researchers to lock specific molecular conformations, improving biological half-life and target receptor binding affinity.
Beyond pharmaceuticals, the intermediate is widely deployed in fine chemical synthesis to construct heterocyclic fungicides, crop protection formulations, and novel industrial surfactants requiring specialized nitrogen heterocycles.
Global supply chain strategies are evolving rapidly. Chemical purchasers prioritize partners who offer transparent supply chains, robust regulatory support, and sustainable green chemistry practices.
Verify that batch CoAs include full chromatographic data (HPLC/GC) and impurity profiles, rather than generic chemical parameter summaries.
Ensure the supplier provides full MSDS/SDS compliance sheets in accordance with GHS frameworks across target destination regions.
Confirm that transit conditions protect temperature-sensitive compounds, ensuring chemical stability throughout international shipping.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Stay updated with our latest peptide research breakthroughs, technical whitepapers, and product updates.
Selank Acetate API is a synthetic heptapeptide active pharmaceutical ingredient composed of the amino acid sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. Originally developed through neuropharmacological research...
View Technical Article
As a professional Thymosin Beta-4 API manufacturer and supplier, we provide high-quality Thymosin Beta-4 peptide API solutions for biotechnology companies and pharmaceutical research organizations...
View Technical Article
BPC-157 API is a synthetic pentadecapeptide that has gained increasing attention in peptide research due to its biological activities related to tissue repair, gastrointestinal protection, and inflammatory regulation...
View Technical Article
With continuous development in neuroscience and peptide technology, neuroactive peptides have become a major focus area. Semax, derived from an ACTH fragment, features unique structural features...
View Technical Article
SS-31 API (Elamipretide, MTP-131) is a synthetic mitochondria-targeting tetrapeptide designed to bind cardiolipin in the inner mitochondrial membrane, supporting cellular bioenergetics...
View Technical ArticleTechnical and Commercial Solutions for Enterprise Chemical Procurement & Quality Verification
Browse our extended product catalog for custom peptides, specialty intermediates, and APIs.
