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A comprehensive technical evaluation of 2-Bromoethylamine Hydrobromide (2-BEA HBr) for commercial pharmaceutical synthesis, bioconjugation, and specialty polymer manufacturing.
| Parameter / Specification | Standard Requirement (Analytical Standard) | Testing Methodology |
|---|---|---|
| Chemical Name | 2-Bromoethylamine Hydrobromide / 2-Bromoethanamine HBr | IUPAC Nomenclature |
| CAS Registry Number | 2576-47-8 | CAS Verification |
| Molecular Formula / Weight | C2H7Br2N / 204.89 g/mol | Mass Spectrometry (MS) |
| Physical Appearance | White to off-white crystalline solid / crystalline powder | Visual Inspection |
| Purity (Assay) | ≥ 99.0% (On dry basis) | Potentimetric Titration / HPLC |
| Melting Point Range | 172.0 °C – 175.0 °C (Dec.) | Capillary Melting Point Apparatus |
| Moisture Content (LOD/KF) | ≤ 0.50% | Karl Fischer Volumetric Titration |
| Residue on Ignition (Ignition Ash) | ≤ 0.10% | Gravimetric Analysis |
| Heavy Metals Content | ≤ 10 ppm | ICP-MS (Inductively Coupled Plasma) |
Engineering perfection in hydrohalogenation: How Gentolex guarantees ultra-low residual bromide impurities and superior crystal structure consistency.
The primary commercial manufacturing pathway involves the nucleophilic substitution of monoethanolamine (MEA) utilizing concentrated hydrobromic acid (HBr) under controlled thermal conditions. The reaction kinetics require meticulous temperature ramping to prevent side-product dimerizations (such as piperazine salt formations).
Crude Bromoethylamine HBr undergoes multi-stage fractional crystallization using anhydrous ethanol-isopropanol solvent systems. This step ensures that trace organic volatiles, unreacted alkanolamines, and inorganic bromide residues are purged below regulatory threshold levels.
Given the hygroscopic nature of 2-Bromoethylamine Hydrobromide, the final vacuum-drying cycle is executed under dry nitrogen blanket conditions at controlled low temperatures. This yields uniform crystal lattice structures with high flowability and zero caking during long-term maritime transit.
Analyzing the pivotal role of 2-BEA HBr as a building block in global APIs, agrochemical formulations, and diagnostic reagent manufacturing.
Essential precursor for the chemical synthesis of cysteamine, taurine derivatives, central nervous system (CNS) agents, and therapeutic peptides. Its dual functionality (ethyl chain capped by a reactive halogen and a primary amine salt) allows smooth ring closure reactions for aziridine and thiazolidine chemistry.
In modern biotechnology, 2-Bromoethylamine Hydrobromide acts as a functional crosslinking agent. It enables the covalent attachment of primary amine tags to thiol-containing bio-polymers, modified peptides, and target oligonucleotides in targeted drug delivery systems.
Used extensively in synthesis pathways for novel systemic fungicides, herbicides, and crop growth regulators. The stability of Gentolex’s bulk material ensures high reaction yield during large-scale industrial condensation reactions.
Acts as an amine-functionalized alkylating agent in cationic polymer production, water treatment flocculants, and advanced phase-transfer catalysts requiring strict ionic purity.
Navigating global chemical compliance with dedicated international hubs, full REACH documentation, and strict cGMP quality management.
Every batch of Bromoethylamine Hydrobromide supplied by Gentolex is supported by comprehensive documentation packages, including Certificate of Analysis (COA), 1H-NMR spectrums, HPLC chromatograms, Mass Spectrometry (MS), and GHS-compliant SDS (Safety Data Sheets).
To overcome international supply chain disruptions, Gentolex maintains direct representation and regional logistics hubs in Mexico and South Africa. This infrastructure enables rapid customs clearing, localized invoicing, and shortened lead times for Latin American and African markets.
Packaged in UN-certified 25kg fiber drums with double PE anti-static moisture-barrier inner liners. Custom palletization and vacuum inertization options are available for long-distance maritime freight or air cargo transport.
Connecting the global life science and chemical industries with guaranteed high-purity APIs, peptide solutions, and custom chemical manufacturing.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard allows us to offer flexible, scalable and cost-effective solutions for clients globally.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
State-of-the-art laboratory testing, high-performance liquid chromatography purification, custom synthesis pathways, and process optimization.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Advancing green chemistry protocols and continuous flow microreactors for bulk halogenation processes.
Gentolex is integrating continuous flow microreactor systems for hydrobromination. This technological upgrade reduces thermal footprint, improves energy efficiency by 35%, and virtually eliminates exothermic risk profiles during bulk 2-BEA HBr synthesis.
Our 250,000 m² chemical production campus incorporates closed-loop solvent distillation units. Hydrobromic acid vapor and organic Mother Liquors are recycled with 98.5% efficiency, aligning with global ISO 14001 environmental management benchmarks.
Implementation of Process Analytical Technology (PAT) using in-line Process Raman Spectrometry allows real-time reaction kinetics tracking, ensuring that every batch meets exact crystalline density and residual solvent limits.
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View DetailsDetailed technical answers to common queries regarding 2-Bromoethylamine Hydrobromide (CAS 2576-47-8) procurement, purity specifications, and handling protocols.
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