Direct factory supply of high-purity clinical and commercial grade Active Pharmaceutical Ingredients (APIs) supporting research institutions and pharmaceutical leaders across Stockholm, Gothenburg, and Medicon Valley.
Sweden stands as one of Europe’s premier hubs for life sciences and biopharmaceutical innovation. With prominent research nodes like the Karolinska Institutet in Stockholm, the AstraZeneca BioVentureHub in Gothenburg, and the thriving cross-border Medicon Valley region in Skåne, the Swedish healthcare cluster is driving pioneering work in gene therapy, messenger RNA (mRNA), small interfering RNA (siRNA), and antisense oligonucleotides (ASOs).
As targeted RNA therapies move rapidly from preclinical pipelines to late-stage commercialization, local research teams and contract manufacturing entities require reliable, ultra-pure Active Pharmaceutical Ingredients (APIs). The demand for modified phosphoramidites, GalNAc-conjugated oligonucleotides, and solid-phase synthesis reagents is accelerating across Scandinavia. To meet these stringent requirements, Gentolex provides custom synthesis and large-scale manufacturing of oligonucleotide APIs backed by rigorous compliance frameworks.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions for specialty chemicals and nucleotide precursors.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Advanced oligonucleotide chemical modifications including phosphorothioate (PS) backbone transformation, 2'-O-methyl (2'-OMe), 2'-fluoro (2'-F), and locked nucleic acid (LNA) chemistry tailored for targeted drug development.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Therapeutic oligonucleotides represent a distinct class of biopharmaceuticals bridging small molecules and biologics. Ensuring high full-length sequence integrity (n-mer content) while strictly limiting truncated short-mer impurities (n-1, n-2) requires state-of-the-art chemical synthesis technology and specialized downstream purification systems.
Utilizing high-capacity multi-column automated synthesizers, our factory carries out precise phosphoramidite chemistry cycle by cycle: Detritylation, Coupling, Capping, and Oxidation/Sulfurization. This methodology yields high coupling efficiencies (>99.5% per step), crucial for long-chain oligos up to 30+ nucleotides.
Post-cleavage and deprotection, raw oligonucleotide crude solutions undergo Ion-Exchange Chromatography (IEX) and Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) purification. Ultrafiltration and nanofiltration steps remove residual organic solvents and inorganic salts, yielding APIs with purity exceeding 98.5%.
Every batch destined for Sweden is verified using LC-MS/MS (ESI-TOF) for exact mass identity, IP-RP-HPLC for purity profiling, ICP-MS for heavy metal impurities, and LAL assay for ultra-low endotoxin testing (<0.05 EU/mg), fully compliant with Ph. Eur. and USP guidelines.
Ultra-pure phosphoramidite raw materials verified by 31P-NMR and HPLC prior to reaction.
Controlled synthesis under inert gas atmosphere preventing moisture contamination.
Prep-HPLC fraction collection followed by lyophilization in Class 100 cleanrooms.
Full Certificate of Analysis (CoA), EDMF/ASMF release paperwork ready for Swedish import clearance.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
Balancing high-tech innovation with cost efficiency is a major priority for Swedish drug developers and procurement directors. Gentolex bridges Chinese large-scale manufacturing infrastructure with Nordic quality standards.
By leveraging our 250,000 m² centralized cGMP production base, clients in Sweden benefit from up to 40% reduction in raw material acquisition costs compared to Western European CDMOs, without compromising quality.
Comprehensive DMF/ASMF dossier support, EDMF registration assistance, and rapid response to Swedish MPA audit questionnaires guarantee seamless regulatory submissions.
Established logistics partnerships with temperature-controlled cold-chain carriers (-20°C / -80°C / dry ice) ensure fast delivery to Stockholm, Gothenburg, Uppsala, and Lund within 3–5 business days.
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Explore our full line of synthetic oligonucleotides, therapeutic peptides, and metabolic API compounds available for immediate Swedish supply.
Key regulatory, technical, and procurement answers tailored for Swedish biopharmaceutical teams and supply managers.
Partner with Gentolex for certified cGMP manufacturing, competitive direct-factory pricing, and expert technical support for your RNA and peptide programs.
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