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1-(Ethoxycarbonyl)piperidin-4-ol (CAS NO.: 1126-00-7), also widely known in industrial organic synthesis as ethyl 4-hydroxypiperidine-1-carboxylate, represents a cornerstone chemical building block used extensively in modern pharmaceutical manufacturing, fine chemical engineering, and peptide API intermediate pathways. Characterized by its stable piperidine core capped with an ethoxycarbonyl protecting group at the nitrogen position and a versatile hydroxyl functionality at position 4, this compound enables selective transformations under demanding chemical environments.
| Parameter / Property | Specification Standard | Analytical Test Method |
|---|---|---|
| Chemical Name | 1-(Ethoxycarbonyl)piperidin-4-ol / Ethyl 4-hydroxypiperidine-1-carboxylate | IUPAC Nomenclature |
| CAS Registry Number | 1126-00-7 | CAS Index Indexing |
| Molecular Formula / Weight | C8H15NO3 / 173.21 g/mol | Mass Spectrometry (MS) |
| Appearance | Clear, viscous pale yellow to colorless liquid / low-melting solid | Visual Inspection |
| Assay Purity (GC/HPLC) | ≥ 99.0% (Commercial Grade) / ≥ 99.5% (Pharma Grade) | GC-FID / HPLC-UV |
| Single Impurity Profile | ≤ 0.10% individual maximum | High-Performance Chromatography |
| Water Content (Karl Fischer) | ≤ 0.3% w/w | KF Titration |
| Residual Solvents | Meets ICH Q3C Requirements | Headspace GC-MS |
Unlike standard market resellers, Gentolex enforces strict batch-to-batch consistency for CAS 1126-00-7. Every batch produced in our standard production facilities undergoes full spectral validation including 1H-NMR, 13C-NMR, LC-MS, and elemental analysis to ensure zero trace metal contaminants and unreacted chloroformate species.
Continuous flow innovations, catalytic hydrogenation efficiency, and green chemistry initiatives driving multi-ton production scalability.
Controlled carbamoylation of 4-hydroxypiperidine utilizing ethyl chloroformate under strict automated temperature and pH feedback loops. Achieves >98.5% conversion with minimal byproduct formation.
Transition from traditional batch reactors to micro-channel continuous flow technology. Optimizes heat dissipation, drastically reduces contact times, and eliminates exothermic runaway risks.
Integrated closed-loop solvent distillation systems recover >95% of reaction solvents (e.g., dichloromethane, ethyl acetate), dramatically reducing carbon footprint and volatile organic compound emissions.
Advanced catalytic reduction routes using heterogeneous noble metal catalysts under mild pressure. Ensures precise chemo-selectivity without disrupting the ethoxycarbonyl protective backbone.
The industrial roadmap for 1-(Ethoxycarbonyl)piperidin-4-ol is rapidly evolving toward greener bio-compatible reaction pathways and automated continuous processing. As global pharmaceutical pipelines demand tighter control over genotoxic impurities, Gentolex is pioneering automated inline process analytical technology (PAT) using real-time Near-Infrared (NIR) spectroscopy. This technological shift guarantees that every metric ton of CAS 1126-00-7 shipped from our facility complies with emerging international regulatory mandates.
Market expansion, supply dynamics, and economic drivers shaping piperidine derivative consumption across North America, Europe, and Asia-Pacific.
The market for piperidine-based intermediates, particularly 1-(Ethoxycarbonyl)piperidin-4-ol, is experiencing sustained compound annual growth (CAGR) driven by the aggressive expansion of novel therapeutic candidate discovery. According to chemical industry intelligence, functionalized piperidines serve as essential pharmacophores in over 20% of top-selling small-molecule drugs worldwide.
Driven by intensive oncology and neuropharmacology R&D. High demand for pharma-grade (>99.5%) CAS 1126-00-7 for early-stage API synthesis and phase I-III clinical trial drug candidates.
Focuses heavily on strict REACH compliance and environmental regulations. Prefers suppliers with audited cGMP quality control standards and low residual solvent metrics.
China serves as the global primary manufacturing base for 1-(Ethoxycarbonyl)piperidin-4-ol, supplying raw materials and intermediate precursors with unmatched scale and cost efficiency.
Growing regional markets across Latin America (especially Mexico) and Africa (South Africa hub) expanding local API processing and crop protection manufacturing capacities.
How downstream industries utilize 1-(Ethoxycarbonyl)piperidin-4-ol for advanced synthesis and industrial formulations.
Key synthon for central nervous system (CNS) therapeutics, antihistamines, novel analgesics, and targeted receptor agonists. The hydroxyl group allows facile etherification, esterification, and nucleophilic substitution.
Serves as a structural backbone in high-efficiency fungicides, selective herbicides, and pest control agents requiring nitrogen-heterocyclic cores to enhance biological selectivity and environmental decay rates.
Utilized as a specialized protecting reagent or conformational constraint modifier during liquid-phase peptide synthesis (LPPS) and customized pharmaceutical conjugate design.
Acts as an intermediate for specialty polymer additives, liquid crystal precursors, and specialty surfactants where high thermal stability and amine functionality are desired.
Unmatched production scale, cost-effective logistics, and global support networks provided by Gentolex Group.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our overall factory construction spans an area of 250,000 square meters designed under rigorous international standards to offer flexible, scalable, and cost-effective solutions for global pharmaceutical and industrial partners.
With 250,000 square meters of dedicated production space, we operate reaction vessels ranging from 500L glass-lined reactors to 10,000L stainless steel industrial systems.
We source raw starting materials directly from basic chemical plants in high volumes, shielding our international buyers from price volatility and global supply disruptions.
Dedicated international branch presence in Mexico and South Africa provides local customs assistance, localized currency transactions, and real-time technical support.
End-to-end solutions for pharmaceutical synthesis, custom peptide manufacturing, and turnkey facility setup.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Building trusted global partnerships through certified excellence and international infrastructure.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
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Technical clarification, batch procurement guidelines, and compliance documentation for global buyers.
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