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Molecular dynamics, chelation pathways, structural integrity, and industrial synthesis benchmarks.
Oxyquinoline Sulfate (also known as 8-hydroxyquinoline sulfate, bis(8-hydroxyquinolinium) sulfate) is a potent heterocyclic organic compound with the molecular formula (C9H7NO)2·H2SO4. Its primary broad-spectrum antimicrobial activity originates from its unique metal-chelating properties. By forming stable hexacoordinate complexes with essential trace divalent metal ions—such as Fe²⁺, Cu²⁺, and Zn²⁺—it effectively deprives pathogenic microorganisms of vital metabolic cofactors. This chelation disrupts fungal cell membrane permeability, inhibits key respiratory enzymes, and blocks RNA polymerase activity.
Commercial-grade Oxyquinoline Sulfate appears as a fine, microcrystalline yellow powder possessing a faint saffron-like odor. It demonstrates excellent solubility in water (approx. 1g in 1mL water) while remaining sparingly soluble in ethanol and insoluble in ether. The crystalline salt structure exhibits superior thermal stability under ambient storage conditions, making it an exceptional active constituent for both liquid concentrate formulations and wettable powder (WP) matrices.
| Property Parameter | Specification Value | Testing Standard / Method |
|---|---|---|
| CAS CAS Registry Number | 134-31-6 | Global Chemical Index |
| Formula Molecular Formula | (C9H7NO)2 · H2SO4 | Mass Spectrometry |
| Assay Active Content (HPLC) | 98.5% – 101.5% (Dry Basis) | USP / EP Standard Chromatographic Assay |
| Appearance Physical State | Yellow crystalline powder | Visual Inspection |
| Melting Melting Point Range | 175°C to 178°C (Decomposition) | Capillary Method |
| Solubility Aqueous Solubility | Highly Soluble (pH 3.0 - 4.5) | Gravimetric Solubility Test |
| Residue Loss on Drying (LOD) | ≤ 0.50% | Vacuum Drying @ 105°C |
| Metals Heavy Metal Impurities | ≤ 10 ppm (Lead/Arsenic) | ICP-MS Spectrometry |
How global manufacturers deploy Oxyquinoline Sulfate across agriculture, personal care, and veterinary chemistry.
In modern systemic crop protection, Oxyquinoline Sulfate serves as a vital bactericide and fungicide. It is widely applied in floriculture, horticulture, and soil sterilization programs to mitigate soil-borne vascular wilt fungi such as Fusarium oxysporum, Verticillium, and Phytophthora spp. It prevents post-harvest fruit decay and protects ornamental greenhouse plants from bacterial soft rot without inducing systemic phytotoxicity when applied at recommended dilutions.
Formulators in animal health integrate Oxyquinoline Sulfate into topical wound sprays, antiseptic gels, and udder-wash formulations for dairy livestock. Its prolonged antimicrobial residual action fights Gram-positive and Gram-negative pathogens, controlling superficial bacterial lesions, ringworm (dermatophytosis), and localized equine or bovine skin infections without causing aggressive tissue irritation.
In human OTC pharmaceuticals, the compound acts as a active antiseptic agent in hemorrhoidal ointments, liquid bandage compositions, and topical anti-fungal solutions. Due to its broad microbicidal window and high efficacy at low concentrations, it is also selected as a preservative system in technical cosmetics to suppress microbial contamination in high-water formulations.
Industrial chemical operations utilize 8-hydroxyquinoline sulfate as a stabilizing agent and biocide in textile treatment, leather tanning, and wood preservative formulations. It prevents fungal rot in natural fibers during oceanic transits and prevents microbial sludge formation in industrial cooling towers and aqueous cutting fluids.
Analytical research laboratories deploy pure grade Oxyquinoline Sulfate in gravimetric analysis and spectrophotometric metal extraction protocols. Its capability to selectively bind trace metals allows accurate quantification of aluminum, magnesium, and zinc ions in complex geological and metallurgical specimens.
Emerging agronomic applications incorporate micro-encapsulated Oxyquinoline Sulfate into smart polymeric matrix coatings. This slow-release mechanism delivers prolonged antimicrobial defense for high-value seed coatings, safeguarding germinating seedlings against damping-off disease during cold, wet spring conditions.
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Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
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Navigating EU REACH, US FDA EPA standards, and localized agricultural compliance across Latin America & Africa.
Our manufacturing processes for Oxyquinoline Sulfate strictly adhere to European Chemicals Agency (ECHA) standards. Full REACH registration guarantees that export shipments comply with heavy chemical safety guidelines, enabling seamless clearance for European chemical formulators and distributors.
For client distribution within the United States, our batches comply with EPA active ingredient parameters for agricultural pesticide registration, alongside FDA guidelines for topical antiseptic and veterinary pharmaceutical excipients. Drug Master File (DMF) documentation is available for pharmaceutical clients upon request.
To address specialized regional requirements, Gentolex maintains established strategic distribution representatives in Mexico and South Africa. This localized presence ensures shortened order lead times, simplified customs clearance, flexible localized currency settlement options, and dedicated on-site technical support.
Pioneering green synthesis chemistry and advanced antimicrobial complexation.
Gentolex is committed to reducing environmental impact through eco-friendly catalytic synthesis. Our current R&D initiatives focus on eliminating hazardous solvent residue during the sulfation phase of 8-hydroxyquinoline, achieving zero liquid discharge (ZLD) during industrial washing cycles, and improving overall atom economy by up to 14%.
Next-generation agricultural applications demand controlled-release active ingredients. Gentolex is developing nanostructured lipid carrier (NLC) complexes for Oxyquinoline Sulfate. This targeted delivery methodology enhances UV photo-stability, extends crop protection intervals by 40%, and reduces overall active ingredient usage per hectare.
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