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Carbobenzoxy Chloride (CAS No. 501-53-1), also widely designated as Benzyl Chloroformate or Cbz-Cl, represents a foundational organochlorine derivative indispensable to modern organic synthesis, pharmaceutical manufacturing, and complex peptide chain assembly. Serving as an elite protective agent for amine functional groups, Cbz-Cl enables chemo-selective transformations across intricate multi-step synthetic routes.
Formula: C8H7ClO2
Molecular Weight: 170.59 g/mol
Assay (GC): ≥ 99.5% Standard
Appearance: Clear, Colorless Liquid
Density: 1.195 g/cm³ at 20°C
Reacts quantitatively with primary and secondary amines under basic conditions (Schotten-Baumann conditions) to form carbamate derivatives ($R-NH-Cbz$) that resist nucleophilic attacks and alkaline hydrolysis.
Cleavage is smoothly executed via mild catalytic hydrogenolysis ($H_2, Pd/C$) yielding inert toluene and carbon dioxide, or via strong acidolysis ($HBr/AcOH$), eliminating risks of thermal degradation.
| Parameter Test | Industrial Standard | High-Purity API Grade | Analytical Method |
|---|---|---|---|
| Assay Purity (GC) | ≥ 98.5% | ≥ 99.5% | Gas Chromatography |
| Free Benzyl Chloride | ≤ 0.5% | ≤ 0.1% | HPLC / GC-MS |
| Free Hydrochloric Acid (HCl) | ≤ 0.2% | ≤ 0.05% | Titration |
| Phosgene Residue | ≤ 50 ppm | Undetectable (< 5 ppm) | Spectrophotometry |
| Water Content (Karl Fischer) | ≤ 0.1% | ≤ 0.02% | ASTM E203 |
As a premier OEM manufacturer, Gentolex supplies scalable quantities of Carbobenzoxy Chloride to drive high-stakes innovations across diverse global industrial sectors.
In therapeutic peptide manufacturing (such as insulin analogs, GLP-1 receptor agonists like Tirzepatide, and neuro-active peptides like Semax and Selank), controlling secondary reactions is paramount. Cbz-Cl is utilized to block the α-amino position during fragment condensation. Its compatibility with various side-chain protective groups guarantees high crude purity and maximum overall yields.
Carbobenzoxy Chloride acts as a strategic structural block in synthesizing β-lactam antibiotics, antiviral agents, and specialized oncology drugs. By shielding sensitive nitrogen centers during harsh alkylation or acylation phases, Cbz-Cl minimizes drug degradation pathways and guarantees compliance with strict cGMP organic impurity thresholds.
In functional polymer chemistry, Cbz-Cl is employed to modify polyurethane backbones, functionalized polyamino acids, and biomimetic hydrogels. The introduction of hydrophobic benzyl carbamate moieties modulates polymer swelling, enzymatic degradation rates, and mechanical tensile strength for biomedical implants.
Modern crop protection demands highly targeted pesticide and herbicide active molecules. Cbz-Cl provides precise derivatization of amino-functionalized agrochemical intermediates, enhancing environmental stability, lowering bio-accumulation risks, and improving systemic target engagement.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa. Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
Our main services focus on supplying peptides APIs and Custom Peptides, FDF license out, Technical Support & Consultation, Product Line and Lab Setup, Sourcing & Supply Chain Solutions.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
State-of-the-art analytical research labs equipped with high-pressure hydrogenation, continuous flow micro-reactors, and high-performance gas/liquid chromatography.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
Carbobenzoxy Chloride requires highly specialized handling, corrosion-resistant packaging, and strict hazardous transport compliance (UN 1728, Class 8 Corrosive Sub-risk). Gentolex ensures seamless cross-border distribution with localized emergency response and regulatory backing.
To prevent self-decomposition and HCl gas buildup, Cbz-Cl is packaged in specialized fluorinated drums under an inert nitrogen blanket, maintained under temperature-controlled shipping conditions (+2°C to +8°C or dry ice for long ocean transit).
Every OEM shipment is dispatched with comprehensive regulatory portfolios including Certificate of Analysis (COA), Safety Data Sheet (SDS / GHS compliant), Gas Chromatography Purity Spectrum, and REACH registration support for EU importers.
With direct commercial entities and inventory warehouses located in Mexico and South Africa, Gentolex drastically reduces shipping lead times for South American and African biopharmaceutical enterprises.
As the chemical industry transitions toward sustainability and AI-driven process optimization, Gentolex leads the adoption of green chemistry practices in protecting reagent production.
Transitioning from traditional batch reactors to continuous flow technology minimizes hold-up volumes of phosgenation intermediates, dramatically reducing hazardous exposure risks while improving batch-to-batch selectivity to > 99.8% purity.
Development of alternative reaction media and recyclable catalyst frameworks during Cbz protection cycles, eliminating aromatic hydrocarbon emissions and lowering environmental carbon footprints across multi-ton manufacturing.
Deploying real-time Process Analytical Technology (PAT) using inline Raman and FT-IR spectroscopy to monitor impurity formation during distillation, ensuring instant quality verification prior to packaging.
Stay informed with the latest API synthesis breakthroughs, peptide engineering updates, and regulatory changes from Gentolex chemists.
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View DetailsComprehensive answers regarding OEM Carbobenzoxy Chloride sourcing, chemical stability, packaging, and custom batch synthesis.
Gentolex provides Carbobenzoxy Chloride (CAS 501-53-1) in high-purity industrial grade (≥ 98.5%) and ultra-pure API peptide synthesis grade (≥ 99.5% by GC). Gas chromatography spectrum reports accompany every commercial batch.
Due to its sensitivity to moisture and propensity to release HCl gas, Cbz-Cl is sealed in heavy-duty fluorinated HDPE drums, stainless steel pressure containers, or glass-lined steel vessels under a dry nitrogen head. Shipping is executed via temperature-monitored refrigerated cargo vessels.
Yes. Operating an expansive 250,000 m² production complex, Gentolex specializes in custom contract manufacturing (CMO/CDMO), tailoring specifications, moisture caps, impurity limits, and private labeling to your exact regulatory and engineering demands.
N-Cbz groups are typically removed via catalytic hydrogenolysis over 5-10% Palladium on Carbon (Pd/C) in methanol or ethanol under atmospheric hydrogen pressure. Alternatively, acidolysis using HBr in glacial acetic acid or trifluoromethanesulfonic acid (TFMSA) is utilized when hydrogenolysis-sensitive functional groups are present.
Gentolex serves clients across North America, Europe, Asia-Pacific, Latin America, and Africa. We maintain specialized regional representative teams and warehouse hubs in Mexico and South Africa for streamlined customs clearance and quick delivery.
Standard documentation includes a comprehensive Certificate of Analysis (COA), High-Performance Liquid Chromatography (HPLC) spectrum, Gas Chromatography-Mass Spectrometry (GC-MS) profiles, Proton NMR, MSDS/SDS, and REACH compliance statements where applicable.
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