As a global primary OEM manufacturer, Gentolex specializes in scalable, high-purity chemical synthesis of organobromine building blocks, key API intermediates, and complex peptide reagents.
Our core manufacturing infrastructure spans an overall standard chemical production complex of 250,000 square meters operating strictly under international regulatory frameworks. With integrated backward raw material access and advanced batch-to-continuous flow technology, we deliver reliable, cost-efficient, and cGMP-compliant Bromo Ethyl Amine (2-Bromoethylamine Hydrobromide, CAS 2576-47-8) solutions tailored for international pharmaceutical, agrochemical, and specialty material enterprises.
2-Bromoethylamine Hydrobromide (CAS 2576-47-8; C₂H₇BrN·HBr; MW 204.89 g/mol) represents a quintessential bifunctional synthon in modern organic synthesis. Containing both a primary nucleophilic alkylating site and a protected amine core, its reactive versatility underpins numerous complex synthesis pathways.
The terminal halogen atom functions as a superior leaving group under basic or neutral conditions, facilitating rapid nucleophilic substitution ($\text{S}_\text{N}2$) reactions with thiols, primary/secondary amines, and phenoxide ions.
Under controlled basic liberation, 2-bromoethylamine undergoes intramolecular cyclization to form aziridine (ethyleneimine), an exceptionally reactive intermediate used to incorporate aminoethyl functionality into target active molecules.
By producing 2-bromoethylamine as a hydrobromide salt ($\text{HBr}$), the free amine's spontaneous self-condensation into piperazine derivatives is completely inhibited, guaranteeing long-term shelf stability under inert storage conditions.
| Parameter | Analytical Specification | Testing Methodology |
|---|---|---|
| Chemical Name | 2-Bromoethylamine Hydrobromide / Bromo Ethyl Amine HBr | IUPAC Nomenclature |
| CAS Registry Number | 2576-47-8 | CAS Database |
| Appearance | White to off-white crystalline powder | Visual Inspection |
| Assay (Purity) | ≥ 99.0% (Typically 99.3% - 99.8%) | Titration / HPLC Assay |
| Melting Point | 172°C - 175°C (dec.) | Capillary Melting Method |
| Water Content (Karl Fischer) | ≤ 0.5% | Coulometric Karl Fischer Titration |
| Residual Solvents | Meets ICH Q3C Guidelines | Headspace Gas Chromatography (HS-GC) |
Due to its bifunctional reactivity, OEM Bromo Ethyl Amine is heavily integrated into commercial value chains across key global industrial sectors:
In pharmaceutical synthesis, 2-bromoethylamine hydrobromide serves as an ethylamine donor to construct nitrogen-containing heterocycles, central neuroreceptors, and biological linkers. It plays a critical role in the synthesis of cysteamine, taurine derivatives, central nervous system (CNS) agents, and modified amino acid linkers utilized in solid-phase peptide synthesis (SPPS) and antibody-drug conjugates (ADCs).
Agrochemical chemical synthesis uses bromo ethyl amine derivatives to introduce aminoethyl side-chains into modern insecticides, systemic fungicides, and plant growth regulators. The precision functionalization allows enhanced lipid solubility and bio-absorption in target agronomic formulations.
Through quaternization or polycondensation, bromo ethyl amine intermediates are converted into cationic polyelectrolytes, flocculants, and antimicrobial surface coatings. The terminal amine functions as an anchor point for cross-linking polymeric matrices used in industrial water clarification and ion-exchange resin modification.
In bio-analytical chemistry, bromo ethyl amine acts as a alkylating reagent to introduce amine handles onto nucleic acids, fluorescent dyes, and affinity ligands. It facilitates specific covalent modification of thiol groups in native proteins without compromising overall tertiary structural integrity.
Traditional batch bromination of ethanolamine frequently faces thermal runaways, localized concentration spikes, and impurity accumulation (e.g., formation of di-halo side products). Gentolex has modernized its OEM production facilities with continuous flow microreactor engineering.
By shifting from conventional glass-lined batch reactors to continuous flow corrosion-resistant Hastelloy-C micro-reactors, we achieve precise residence time control and sub-second heat dissipation during hydrobromination. This mitigates byproduct formation by over 92%.
Our green manufacturing infrastructure incorporates closed-loop hydrobromic acid recovery systems. Waste streams are neutralized and recycled, reducing chemical oxygen demand (COD) while drastically lowering overall raw material consumption metrics.
Every industrial batch undergoes stringent impurity profiling via high-performance liquid chromatography (HPLC) paired with mass spectrometry (LC-MS). Potential toxic impurities such as 1,2-dibromoethane are rigorously constrained below 50 ppm.
Global chemical procurement requires not only technical chemical purity, but also operational stability, cost predictability, and shipping reliability. Gentolex leverages China's complete chemical manufacturing ecosystem to provide unprecedented supply chain security.
Gentolex’s manufacturing hubs maintain long-term strategic contracts and direct pipeline access to elemental bromine production centers in Shandong and Jiangsu chemical parks. This direct integration insulates our multinational OEM clients from spot market volatility in elemental bromine prices.
Our overall factory construction area of 250,000 square meters under international standard offers flexible, scalable, and highly cost-effective manufacturing solutions. From multi-kilogram pilot batches to multi-ton commercial orders, our facilities scale seamlessly to match demand cycles.
Gentolex Group has been serving customers across more than 10 countries. To provide immediate technical sales response, dynamic inventory holding, and direct logistics coordination, overseas regional representative offices have been established in key hubs including Mexico and South Africa.
Due to the hygroscopic nature of 2-bromoethylamine hydrobromide, our export shipments are packed in double vacuum-sealed PE bags with moisture-proof aluminum foil lining, enclosed within UN-approved fiber drums (25 kg net weight) with desiccant inserts to preserve compound stability across long ocean transits.
Navigating regulatory standards across North America, the European Union, and Asia-Pacific demands robust Quality Assurance (QA) and complete regulatory documentation support from chemical suppliers.
Gentolex provides full support for REACH registration dossiers in Europe and Toxic Substances Control Act (TSCA) inventory validation for US imports, ensuring uninterrupted border clearance.
Our production facilities operate under ISO 9001:2015 quality management and ISO 14001:2015 environmental standards. Pharmaceutical-grade intermediate lines adhere to strict cGMP guidelines.
Every commercial batch is accompanied by comprehensive documentation: Certificate of Analysis (CoA), Safety Data Sheet (MSDS/SDS adhering to GHS), Method of Analysis (MoA), and Stability Data.
Gentolex’s goal is to create opportunities connecting the world with better services and guaranteed products. Up to date, Gentolex Group has been serving customers from more than 10 countries, specially, representatives are established in Mexico and South Africa.
An overall factory construction area of 250,000 square meters under international standard to offer flexible, scalable and cost-effective solutions.
Gentolex offers an extensive range of APIs and intermediates for development study and commercial application with cGMP standard from long-term collaborations. Documents and Certificates are supported to customers worldwide.
Continuous R&D investment powering custom organic synthesis, process engineering, scale-up chemistry, and high-purity chemical reagent purification.
For those clients who prefer to avoid the complexity of dealing with multiple points of contact, we provide extra customized procurement services with the most superior and comprehensive supply chain sources.
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